Baxter International Inc.

Fenwal, Inc.

Baxter Travenol Laboratories, Inc.

Quadra Logic Technologies, Inc.

John Foley

Arnold Bilstad

Jeffrey E. Miripol

William R. Bratten

Dean Glash

John T Foley

Richard I Brown

Arnold C Bilstad

David E Cerny

Brian C Case

Lan T Nguyen

Sidney T Smith

Jonathan W Prendergast

Kyungyoon Min

William R Bratten

Ludwig Wolf, Jr

Timothy J Patno

Dean M Glash

Jeffrey E Miripol

Mark P Sahlin

Daniel R Boggs

William Henry Cork, Iii

Kevin Krause

Joseph C West, Jr

Douglas Newlin

Jeffrey Maher

Robert Crampton

Walker P Woodworth

Christopher Mikkelson

David V Bacehowski

Daniel F Bischof

Joseph Intonato

Dale R Ellis

Matthew J Schoonover

Abinash Nayak

John W Barry

Timothy A Johnson

David Owen Packles

Benoit Dion

Jennifer A Hollenstein

Minh D Tran

Clint D Luckinbill

Richard J Brown

Richard L Brown

Kyungoon Min

Matthew Sonier

Michael Stonefield

Gary Kunz

Jennifer A Pierce

Robert Cairone

James R Bradley

Thomas Cortese

Yu Feng

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

Systems and methods for use and control of an automated separator with adsorption columns

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution

Systems and methods for determining when a fluid supply container of a blood processing apparatus becomes empty. The system uses a scale to monitor and detect when a fluid supply container is empty based on the rate of change of the container weight and whether the container weight is below a pre-established threshold, and a controller receives a signal from the scale and controls the operation of a pump to stop pumping when the fluid supply container is empty.

Automatic fluid container switching in a blood processing system

Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

Centrifugation system with red blood cell barrier

Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure.

Systems and methods for controlling plasma flow rates for therapeutic exchange procedures

Methods are provided for collecting platelet-rich plasma. A disposable flow circuit is mounted to a fluid processing device having a fluid separation chamber and an injection device. A fluid containing plasma and platelets is continuously conveyed from a fluid source into the fluid separation chamber and processed to produce platelet-rich plasma. At least a portion of the platelet-rich plasma is automatically conveyed from the fluid separation chamber into the injection device, which is directly connected to a pump device such that at least a portion of the platelet-rich plasma from the fluid separation chamber is automatically conveyed into the pump device prior to being conveyed into the injection device. The injection device with the platelet-rich plasma is then detached from the disposable flow circuit.

Methods for extracting platelet-rich plasma for therapeutic injection

Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a blood separation chamber configured to separate blood into first and second blood components and an outlet line for removing at least a portion of the first blood component from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the first blood component in the outlet line. The system also includes a controller programmed to select between the primary optical sensor assembly and the secondary optical sensor assembly for monitoring contamination of the first blood component. The system is particularly advantageous for preventing contamination of separated plasma which is lipemic or hemolytic.

Control of interface between separated blood components under lipemic and hemolytic conditions

A method is disclosed for priming a kit for use in a therapeutic apheresis procedure with previously-collected blood prior to flowing the patient's whole blood into the inlet line of the kit, as part of a procedure in which a selected blood component is separated from a patient's whole blood, and replaced with a previously-collected blood component. The operator enters into the controller of the separation device the hematocrit value of the previously-collected blood. Then, in response to prompts by the controller, the operator enters a target hematocrit value for the previously-collected blood and an identification of the portion of the kit to be primed. The identified portion of the kit is automatically primed with the previously-collected blood. The patient is then connected to the inlet line of the kit in response to a prompt from the controller and the therapeutic procedure is commenced.

Methods for automated blood prime

Systems, methods, apparatus, and computer readable media are provided for disposable component authentication with respect to a biological fluid processing device instrument. An example instrument authentication system includes a computer facilitating configuration and operation of the biological fluid processing instrument using a disposable component. A first interface is provided by the computer and is used by a service technician to configure the biological fluid processing instrument for a number of disposable components and to provide a service technician with a validation code. A key generator is to accept the validation code from the service technician and generate an authentication key in response to the entered validation code. A second interface is provided by the computer, the second interface prompting the service technician to enter an authentication key, wherein the authentication key authorizes use of a certain number of disposable components for the biological fluid processing instrument.

Authorization scheme to minimize the use of unauthorized medical device disposables on a medical device instrument

Systems, methods, and computer readable media are provided for product options calculation with respect to an apheresis instrument. An example product options calculator system for an apheresis instrument includes a preset information module including preset information regarding blood component products and configuration information. The system also includes a donor specific input module receiving donor specific information about a blood donor from a user. The system further includes a blood product options calculator calculating available blood component collection procedure options and associated settings within the constraints of the preset information and the donor specific information from which a user can choose to configure the apheresis instrument. Additionally, the system includes a display for displaying available component collection options to the user with respect to the apheresis instrument. The system also includes an interface accepting user input.

Product options calculator for a blood processing system

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Wheeling, IL, United States of America

John T Foley