Amgen Inc.

John T Colyer

Jason S Tedrow

Robert Ronald Milburn

Sheng Cui

Liang Huang

Matthew Bio

Steven Mennen

Yuanqing Fang

Babak Riahi

Kyle Quasdorf

Eric A Bercot

Andrew Thomas Parsons

Austin G Smith

Philipp C Roosen

Michael T Corbett

Matthew G Beaver

Oliver Thiel

Alan H Cherney

Johann Chan

Gabrielle St-pierre

Rahul P Sangodkar

Michael A Lovette

Ari Ericson

Michal Achmatowicz

Joanna Robinson

Daniel J Griffin

Kyle D Baucom

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

Ring closing synthesis of macrocyclic MCL-1 inhibitor intermediates

The present invention relates to processes for preparing protected glyceraldehydes, such as (hydroxy)methanesulfonates. In addition, the invention relates to thiadiazoles, particularly 3-diooxolanyl-thiadiazoles.

Method for the preparation of thiadiazoles

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Newbury Park, CA, United States of America

John T Colyer