3m Innovative Properties Company

Minnesota Mining and Manufacturing Company

John T Capecchi

Randall L Knoll

Carl Franzblau

Donald F Gibbons

Howard M Leibowitz

Vickery Trinkaus-Randall

Matthew T Scholz

Jeffrey F Andrews

William B Isaacson

Manley R Johnston

Dianne L Gibbs

Larry R Krepski

Steven M Heilmann

David B Olson

Steven B Heinecke

James E Aysta

James S Stefely

Donald H Lucast

John P Vasilakos

Patricia J Brandt

Joseph M Beaurline

Peter M Seiler

Scott D Anderson

Oh-Seung Kwon

Karen Elizabeth Johnson

James M Elvecrog

James Elvecrog

Karen E Johnson

Injectable formulations comprising ethanol, sesame oil, and an Immune Response Modifier compound are disclosed. Methods of making the formulations and methods of using the formulations for treatment of a disease in a subject, e.g., neoplastic disease, comprising injecting the formulations into a subject hi need of treatment, are also provided.

Sesame oil based injection formulations

Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).

Antimicrobial compositions and methods

Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula &#x2014;[O&#x2014;R&#x2014;C(O)]&#x2014; wherein: 'R' is a linear, branched, or cyclic organic group, 'n' is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.

Medicinal compositions and method for the preparation thereof

An article comprising a substrate, and a textured, matte-finish, low adhesion backsize coating on one surface of the substrate, wherein the coating comprises polyvinyl carbamate having nitrogen-bonded hydrocarbon side chains which provide terminal alkyl groups more than five carbons in length.

Textured, matte-finish, low adhesion coatings

An adhesive dressing includes an adhesive composition in the form of a substantially continuous layer on at least a portion of a conformable backing in which the adhesive composition and the backing are selected such that the adhesive dressing has an Inverted Buffered Saline Moisture Vapor Transmission Rate of at least about 9000 g/m.sup.2 /24 hrs.

Moisture-regulating adhesive dressing

A corneal prosthesis including an optical element having an optically transparent central portion and an anterior surface capable of supporting a layer of epithelial cells, the optical element being made of optical material having water content between 50% and 90% and a tensile strength greater than 20 kg/cm.sup.2, and a porous outer skirt secured to the periphery of said element, said skirt being sufficiently porous to permit cell ingrowth and tissue attachment. Also disclosed are methods of making, seeding and using corneal implants having epithelial layers thereon and porous implant material of a coherent mass of randomly oriented fibers having an interconnected network of pores.

Surgical method for implanting a corneal implant

Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.

Azlactone-functional substrates, corneal prostheses, and manufacture and

Corneal implants and manufacture and use thereof

A holding device for seeding cells on a surface of a prosthesis including chamber means for partially defining a first chamber with the first surface, and sealing means for providing a seal between the chamber means and the prosthesis so as to isolate the seeding surface from another portion of the prosthesis.

Prosthesis holding device

Growing community of inventors

Oakdale, MN, United States of America

John T Capecchi