Corning Incorporated

Corning Incorpotated

John Stephen Peanasky

Steven Edward DeMartino

Robert Anthony Schaut

Andrei Gennadyevich Fadeev

Theresa Chang

Christopher Lee Timmons

Santona Pal

Dana Craig Bookbinder

Wendell Porter Weeks

Chandan Kumar Saha

Ming-Jun Li

Stephan Lvovich Logunov

Robert Michael Morena

Paul Stephen Danielson

Natesan Venkataraman

William James Miller

Ronald Luce Verkleeren

James Ernest Webb

Kevin Patrick McNelis

Sinue Gomez-Mower

Daniel Warren Hawtof

Qi Wu

Alexander Mikhailovich Streltsov

Steven Edward Demartino

Kaveh Adib

Joseph Michael Matusick

Patrick Joseph Cimo

Douglas Miles Noni, Jr

Connor Thomas O'Malley

Amber Leigh Tremper

Shivani Rao Polasani

Christy Lynn Chapman

Weirong Jiang

Christie Leigh McCarthy

Jared Seaman Aaldenberg

Kristen Dae Waight

Eric Lewis Allington

Bryan James Musk

Susan Lee Schiefelbein

James Patrick Hamilton

Adam Robert Sarafian

Michael Clement Ruotolo, Jr

Melinda Ann Drake

Kyle Christopher Hoff

John Frederick Bayne

Jamie Lynne Morley

David Henry

Anping Liu

Edward John Fewkes

Ye Fang

Joydeep Lahiri

Mark Francis Krol

Valerie Claudine Lacarriere

Leonard Thomas Masters

Paul Ernest Gagnon, Jr

Linda Sue Baker

Kristi Lynn Simonton

Hongming Wang

Jean-Jacques B Theron

David Charles Sauer

Terry T Goodrich

Alicia Marie Gallagher

Michael Clement Ruotolo

Shreya Roy Choudhury

Bryan Henry Smith

Robert Scott Burkhalter

Jun Xi

Dana Craig Brookbinder

A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dand an average sidewall thickness T, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter Nthat is less than the outer diameter Dof the cylindrical body portion. The average wall thickness Tis less than or equal to 0.85*s, wherein sis a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter dthat is closer to the outer diameter Dthan the outer diameter dof any other standard glass cartridge defined by ISO 13926-1:2004.

Glass containers for storing pharmaceutical compositions

Glass articles with coatings are disclosed herein. According to embodiments, a glass article may include a glass body comprising glass and having a first surface and a second surface opposite the first surface, wherein the first surface is an exterior surface of the glass body. A coating disposed on at least a portion of the exterior surface of the glass body. The coated glass article may have an effective throughput rate greater than or equal to 1.10×R, wherein Ris the effective throughput rate of an uncoated glass article in units of parts per minute (ppm).

Glass articles with low-friction coatings

Disclosed herein are glass containers which may include a glass body comprising an alkali aluminosilicate glass composition having a Class HGA1 hydrolytic resistance when tested according to the ISO 720:1985 testing standard. The glass body may have an interior surface and an exterior surface. A heat-tolerant coating may be bonded to at least a portion of the exterior surface of the glass body. The heat-tolerant coating may have a coefficient of friction of less than about 0.7 and is thermally stable at a temperature of at least 260° C. for 30 minutes. The heat-tolerant coating may comprise a polymer, and the heat-tolerant coating may have a thickness of less than or equal to 100 nm.

Delamination resistant glass containers with heat-tolerant coatings

According to one or more embodiments disclosed herein, a coated pharmaceutical package may comprise a glass container comprising a first surface and a second surface opposite the first surface, wherein the first surface is an outer surface of the glass container, and wherein the glass container in an uncoated state has an average light transmittance in the UVB and UVC spectrum of at least 50% through a single wall of the coated package. The coated pharmaceutical package may further comprise a coating positioned over at least a portion of the first surface of the glass container, wherein the coated pharmaceutical package has an average light transmittance in the UVC spectrum of less than 50% through a single wall of the coated package.

Ultraviolet light-blocking coated pharmaceutical packages

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter dof a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Glass containers with delamination resistance and improved damage tolerance

A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes. A horizontal compression strength of the coated glass package is at least 10% greater than an uncoated glass package and the horizontal compression strength is not reduced by more than 20% after undergoing the depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes and then being abraded. The lubricous coating comprises a polymer.

Glass containers with improved strength and improved damage tolerance

Embodiments of the present disclosure are directed to coated glass articles which reduce glass particle formation caused by glass to glass contact in pharmaceutical glass filling lines.

Pharmaceutical glass coating for achieving particle reduction

According to embodiments, a method of making a coated pharmaceutical container, may include: forming a glass tube; forming the glass tube into a pharmaceutical container comprising an interior surface and an exterior surface; and applying a coating to the exterior surface. The coating has a coefficient of friction less than or equal to 0.7 relative to a second pharmaceutical container when tested in a vial-on-vial testing jig under a normal load of 30 N. The coated pharmaceutical container may be thermally stable after depyrogenation at a temperature of at least 260° C. for 30 minutes in air.

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Big Flats, NY, United States of America

John Stephen Peanasky