Amgen Inc.

Glaxosmithkline LLC

Teijin Pharma Limited

John Stellwagen

Laurie B Schenkel

Angel Guzman-Perez

Jennifer Rebecca Allen

Matthew M Weiss

Qingyian Liu

Jerry Leroy Adams

Mark Henry Norman

Ryan D White

Karina Romero

Patricia Lopez

Richard Thomas Lewis

Ted Charles Judd

Deborah Choquette

Robert Michael Rzasa

Qiufen May Xue

Wenge Zhong

Yuan Cheng

Ana Elena Minatti

Nuria A Tamayo

Alex Gregory Waterson

Daniel La

Michael D Bartberger

Alan C Cheng

Russell Graceffa

Paul E Harrington

Daniel B Horne

James A Brown

Markian Myroslaw Stec

Zihao Hua

Philip R Olivieri

Benjamin Charles Milgram

Jason Brooks Human

Oleg Epstein

Xiao Mei Zheng

Wei Zhao

Isaac E Marx

Neil W Johnson

Alessandro Boezio

Scott Howard Dickerson

Thomas Dineen

Randall W Hungate

Shannon Rumfelt

Xinrong Tian

Fang-Tsao Hong

Michele Potashman

George Adjabeng

Nagasree Chakka

Emily Anne Peterson

Hongbing Huang

Tara Renae Rheault

David Edward Uehling

Christiane Boezio

Katrina Woodin Copeland

Kevin Kuntz

Christiane M Bode

Douglas A Whittington

Jane Panteleev

Hua Gao

Hongyu Liao

Daniel C H Lin

Alan H Cherney

Brian Wilson

Keith Hornberger

Kimberly Petrov

Madeleine Kieffer

Shuyan Yi

James R Coats

Jeffrey M Ralph

Issac E Marx

Gregory Schaaf

Richard T Lewis

Angel Guzman-perez

Richard Lewis

The present invention provides a compound of Formula (I):

Cyclopropyl dihydroquinoline sulfonamide compounds

The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. 

Benzimidazole derivatives and their uses

The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

Bicyclic ketone sulfonamide compounds

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, R, R, R, Rand n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II. 

Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, R, R, R, R, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.

Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof

Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein. 

Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, R, R, R, Rand n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.

Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Benzene sulfonamide thiazole and oxazole compounds

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Beverly, MA, United States of America

John Stellwagen