Bio-energy Corporation

Other

Viacell, Inc.

Ribocor, Inc.

John St Cyr

Clarence A Johnson

Terri L Butler

Daniel Grant Ericson

Stephen G Sawada

Dean J MacCarter

George Verlaan

Paul Bradley Addis

Theodore Charles Kelly

Susan S Percival

Linda M Shecterle

Scott Hagerman

Raj Khankari

J Michael Holton

Robin J Henken

Louis W Vasquez

The present invention relates to methods for supplementing the diet of subjects suffering from cardiovascular disease. D-Ribose is given long term alone or in combination with vasodilators in order to improve or maintain the diastolic or systolic function of the subjects.

Compositions and methods for improving cardiovascular function

This invention discloses a method and compositions for treatment or prevention of pulmonary hypertension in a mammal. Representative mammals include humans and horses. The invention further relates to supplements especially beneficial in preventing or stopping the progression of pulmonary hypertension. The supplements include ribose and folate. Additional nutrients include omega-3 fatty acids and gamma-linolenic acid.

Method and compositions for improving pulmonary hypertension

A ribose-related compound is added to whole blood or packed red cells which have suboptimal function as measured by decreased levels of 2,3-DPG in order to rejuvenate the red blood cells to normal function as seen by raised levels of 2,3-DPG. Two representative ribose-related compounds are D-ribose and inosine.

Methods for rejuvenating

Feed supplements for poultry raised using a rapid growth regimen are disclosed herein. The supplements include D-ribose in an amount effective to improve the resistance to cardiomyopathy in the poultry. Methods for feeding poultry are also disclosed herein.

Compositions and methods for feeding poultry

D-Ribose, a buffer and an anticoagulant are added to whole blood or packed red cells to extend function in storage beyond 42 days. Methods are disclosed to rejuvenate suboptimally functional red cells. The methods are comprised of incubation of the cells at 37&#xb0; C. for 10 to 60 minutes in the presence of D-ribose.

Rejuvenation of stored blood

The present invention relates to compositions for supplementing the diet of subjects suffering from cardiovascular or peripheral vascular disease or those at risk for such conditions. Ribose is given alone or in combination with one or a combination of vasodilators, nutrients and vitamins. Preferred vitamins include Vitamins C, B6, B12 and folic acid. Preferred nutrients include glutamine and glucose.

Methods for improving cardiac function

Blood platelets stored in an isotonic, balanced salt solution under standard storage conditions retain function after ten days of storage when micormolar or nanomolar amounts of pentose are added to the solution. The preferred pentoses are D-Ribose, xylulose-5-phosphate and the pentose-related alcohol xylitol.

Compositions for the storage of platelets

The invention is a dual lumen, adjustable cannula assembly which comprises an inner cannula which is moveable within an outer cannula. Each cannula has openings for fluid passage. The assembly may be placed at any region within a body cavity such as the peritoneal cavity, the vena cava, veins or arteries. The inner cannula can be advanced beyond the position of the cannula assembly so as to communicate with a region of the cavity different from that with which the outer cavity communicates.

Dual lumen adjustable length cannulae for liquid perfusion or lavage

D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration of D-Ribose. Methods are also provided for the enhancement of the immune response in isolated leukocytes. Leukocytes are cultured ex vivo in the presence of D-Ribose and transfused into a patient in need of leukocyte augmentation.

Compositions for enhancing the immune response

Precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and/or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.

Compositions for increasing energy in vivo

Persons encountering high altitudes without being acclimatized can prevent or alleviate the symptoms of acute mountain sickness by administration of ribose one to four times a days, beginning immediately on encountering high altitudes and continuing for at least five days.

Method for treating acute mountain sickness

Pentose is administered to mammals to increase athletic performance and reduce fatigue.

Compositions for increasing athletic performance in mammals

A method of determining the viability of a hibernating or stunned myocardial segment comprises the administration of ribose, a vasodilator and an inotropic agent. The preferred agent is dobutamine, which has both a vasodilation and an inotropic effect. The segments may be identified by myocardial imaging by any known means, such as echocardiography, Thallium-201 tracing or positron emission tomography. Ribose is preferably given one minute to three hours prior to administration of the vasodilator and inotropic agents.

Method for determining viability of a myocardial segment

The administration of ribose raises the hypoxic threshold of mammals experiencing a hypoxic condition. The presence of an effective amount of ribose in the tissue of a mammal increases the tolerance to hypoxia and decreases the symptoms of hypoxia in mammals experiencing chronic hypoxia due to cardiovascular disease or peripheral vascular disease. Such mammals are additionally benefited by administration of ribose and a vasodilator or an isotropic agent. Mammals experiencing transient hypoxia from high altitude, anesthesia or exercise are also benefited.

Growing community of inventors

Coon Rapids, MN, United States of America

John St Cyr