Ucbbiopharma Srl

Other

John Spencer Emtage

Diljeet Singh Athwal

John Robert Adair

Graham A Rook

Roland Foulkes

Mark William Bodmer

Martin Rae Wales

CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (78) and (88) and/or (91). The CDR-grafted light chains comprise donor residues at at least one of positions (1) and/or (3) and (46) and/or (47) or at at least one of positions (46, 48, 58) and (71). The CDR-grafted antibodies are preferably humanized antibodies, having non human, e.g. rodent, donor and human acceptor frameworks, and may be used for in vivo therapy and diagnosis. A generally applicable protocol is disclosed for obtaining CDR-grafted antibodies.

Humanised antibodies

Use of estrone derivatives as steroid sulphatase inhibitors

Growing community of inventors

Marlow, United Kingdom

John Spencer Emtage