Emisphere Technologies, Inc.

Virginia Commonwealth University

John Smart

Jun Liao

Andrea Leone-Bay

Sam J Milstein

David Gschneidner

John J Freeman

Kelly Sullivan Kraft

Destardi Moye-Sherman

Nai Fang Wang

Raphael M Ottenbrite

Pingwah Tang

Puchun Liu

Richard Conticello

Eugene N Barantsevitch

Donald J Sarubbi

Doris C O'Toole

Maria Aurora P Boyd

Elizabeth Flanders

Monica Leipold

Maria A P Boyd

David Gscheidner

Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Phenoxy carboxylic acid compounds and compositions for delivering active agents

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Polymeric delivery agents and delivery agent compounds

The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.

Pulmonary delivery of active agents

Polymeric delivery agents and delivery agents compounds

The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.

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Katonah, NY, United States of America

John Smart