Vanrx Pharmasystems Inc.

General Fusion Inc.

John Senger

Juvenal Naing

Christopher Procyshyn

Marcin Czeslaw Cichy

Michel Georges Laberge

Lon William McIlwraith

Douglas Harvey Richardson

Peter Leszek Kostka

Darcy Montgomery

Ryan Walter Zindler

Craig Rathe

Kristin Bell

Carlos Alberto Diaz Guerrero

Yakov Gofman

Lon Mcilwraith

Douglas H Richardson

Ryan Zindler

The system of the invention involves a gloveless aseptic processing system. The automated system is for filling nested pharmaceutical containers with a pharmaceutical fluid substance. A closed sterilizable gloveless isolator chamber is capable of maintaining an aseptic condition, having a sterilization system. The container filling system has a dispensing head for filling the containers, and a container closing system disposed within the gloveless isolator chamber with rams for pushing closures into openings of the nested containers. The container manipulation mechanism is disposed within the gloveless isolator chamber and is capable of positioning the nested pharmaceutical containers within the gloveless isolator chamber including operably disposing the nested pharmaceutical containers with the container filling system and the container closing system. Container tubs sealed by removable covers and contain a container nest bearing a plurality of pre-sterilized pharmaceutical containers.

Apparatus and method for monitoring and controlling the aseptic filling and sealing of pharmaceutical containers with a pharmaceutical fluid using rotary stage

Disclosed are systems and methods for aseptically filling pharmaceutical containers with a pharmaceutical substance and then lyophilizing it. In one general aspect, the system and method can employ a lyophilizer loader subsystem having an interior chamber in communication with an interior chamber of a lyophilizer subsystem via a portal with a sealable door, with the collective interior being aseptically sealable. An articulated robotic arm can be employed to batch transfer to the lyophilizer subsystem container nests bearing the pharmaceutical containers. In one embodiment, the nests may be transferred serially to the loader subsystem, with the articulated robotic arm being configured to transfer the nests of containers in batches to the lyophilizer subsystem. The articulated robotic arm can also be configured to be used to move batches of nests within the lyophilizer subsystem. One implementation includes two articulated arms and a joint rotary wrist driven by two rotary shoulders.

Method and apparatus for loading a lyophilization system

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

Apparatus and method for aseptically filling pharmaceutical containers with a pharmaceutical fluid using rotary stage

Apparatus for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage

Apparatus and method for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage

A reconfigurable nest handling system for handling nests of objects arranged in a predetermined pattern is presented and applied to a system for filling nested pharmaceutical containers with a pharmaceutical fluid. In one general aspect, the system comprises a sterilizable chamber containing a planar rotary stage with tub and nest positioning systems that may be reconfigurable for holding differently sized pharmaceutical container tubs and nests and pharmaceutical closure tubs and nests. The chamber has a rotatable cover removal station, a rotatable filling station with a dispenser head, and camera guided vacuum pickup facilities for handling container and closure nests. The vacuum pickup facilities may be reconfigurable for handling differently sized nests. An associated method for filling the containers comprises establishing an aseptic condition within the chamber; removing covers from a container tub and a container closure tub by operating both the rotary stage and the cover removal station. The vacuum pickup facility transfers into the fiducial locating structure a container nest bearing pharmaceutical containers. The fluid is dispensed into the containers by operating both the rotary stage and the filling station. A container closure nest is placed on the container nest in the fiducial locating structure with closures in correspondence with containers. A ram in the chamber forces the closures into the containers.

Examples of a pressure wave generator configured to generate high energy pressure waves in a medium are disclosed. The pressure wave generator can include a movable piston with a guide through which a piston control rod can move or slide. The pressure wave generator can include a transducer coupled to a medium. During an impact of the piston on the transducer, the control rod can slide in the guide, which can reduce stress on the rod. The pressure wave generator can include a damper to decelerate the control rod, independently of the piston. Impact of the piston on the transducer transfers a portion of the piston's kinetic energy into the medium thereby generating pressure waves in the medium. A piston driving system may be used to provide precise and controlled launching or movement of the piston. Examples of methods of operating the pressure wave generator are disclosed.

Pressure wave generator with movable control rod for generating a pressure wave in a medium

Growing community of inventors

New Westminster, Canada

John Senger