Emd Millipore Corporation

John Saragosa

David DeCoste

Joseph Cianciolo

Michael Furbush

David Decoste

Wilson Moya

Brian Pereira

Joseph William Muldoon

Dennis Wong

Elias G Noukas

James E Kelly

George Gagne

John Cieciuch

Luc Messier

Benjamin Cacace

Shannon Cleveland

Marina Varlamova

Daniel Lamothe

James Dee

Nicholas Vigorito

Kristin Prescott

Stefano Berti Perez

A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.

Articulating biocontainers

A multilayered film for biocontainers, an abrasion-resistant substrate attached to the interior or the exterior side of the film wherein the substrate is one of a polymeric woven fibrous material or a polymeric non-woven fibrous material, a woven fibrous material or a non-woven fibrous material having metal fibers, a woven fibrous material or a non-woven fibrous material having glass fibers, or a woven fibrous material or a non-woven fibrous material having carbon fibers; a polymer backing to attach the substrate to the film, including one of polyolefins, polyurethanes and nylons; an outer protective layer disposed on the outside of the substrate to encapsulate the substrate; and a gas impermeable layer that includes ethylene vinyl alcohol disposed intermediate to the substrate and the outer protective layer.

Abrasion resistant film for biocontainers

A biocontainer film enhanced with an abrasion resistant or 'cut-proof' substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

A fluid transfer system () includes a transfer device () and an interface device (). The transfer device () includes a fluid transfer member () and a transfer coupling member () to align the fluid transfer member () with the interface device (). The interface device () includes a reservoir port (), a fluid transfer member receptacle (), an interface coupling member (), and a reservoir valve (). The interface coupling member () is configured to close the fluid transfer member receptacle () and to couple to the transfer coupling member () and open the fluid transfer member receptacle () to receive the fluid transfer member (). The reservoir valve (), e.g., a sliding seal, is configured to close the reservoir port () from the fluid transfer member receptacle () and to open the reservoir port () to the fluid transfer member () when the fluid transfer member () is positioned in the fluid transfer member receptacle (). The fluid transfer member () can include a plunger assembly configured to open and close the reservoir port ().

Interface and fluid-transfer system

A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit.

Feed bag construction

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Melrose, MA, United States of America

John Saragosa