Cedars-sinai Medical Center

Immunocellular Therapeutics, Ltd.

Precision Lifesciences Group LLC

John S Yu

Keith L Black

Gentao Liu

Bong Seop Lee

Peter Kabos

Moneeb Ehtesham

James Bender

Anthony B Nesburn

Steven L Wechsler

Guey-Chuen Perng

Lincoln A Edwards

James G Bender

Hui Zhu

Yasuharu Akasaki

Compositions of multipeptide vaccines comprising at least seven tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based vaccines presenting epitopes from at least seven tumor associated antigens, and methods of making same, are provided herein. Also, disclosed are methods for treating gynecological and peritoneal cancers using such vaccines.

Cancer vaccines and vaccination methods

Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.

The present invention describes methods of prognosticating patient survival based on an analysis of the ZEB1 gene or gene product. The present invention also describes methods of selecting and/or selecting various therapies based on the analysis of ZEB1, IDH1, PTEN, MGMT and/or RET. Further describes are systems for analyzing ZEB1, IDH1, PTEN, MGMT and/or RET as well as selecting and/or selecting the therapies.

Systems and methods for prognosticating brain tumors

The present invention describes nanoprodrugs of non-steroidal anti-inflammatory drug (NSAIDs) and nanoprodrugs of &#x3b1;-lipoic acid-containing and NSAIDs. These nanoprodrugs have antioxidant properties and stimuli-responsiveness, which can be used to treat various disease conditions.

Nanometer-sized prodrugs of NSAIDs

An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO: 1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO: 1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO: 13). The immunogens can be used in compositions and in the treatment of disorders.

CD133 epitopes

An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can be used in compositions and in the treatment of disorders.

The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS). Methods of synthesizing novel antioxidant mALAs, spontaneous emulsification or nanoprecipitaion thereof to produce antioxidant nanospheres and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are also described. Another aspect of this invention is the use of these antioxidant nanospheres for the preparation of antioxidant particulate delivery system of therapeutic agents.

Antioxidant nanosphere comprising [1,2]-dithiolane moieties

Method of stimulating an immune response (e.g., to treat cancer) include administering to a patient a composition including dendritic cells that present cancer stem cell antigens. Compositions including cancer stem cell antigens are also provided herein.

Cancer stem cell antigen vaccines and methods

The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant camptothecin nanosphere prodrugs and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these antioxidant camptothecin nanosphere prodrugs for the preparation of delivery devices of other pharmaceuticals and/or drugs. Additionally, methods of treating cancer with the camptothecin and antioxidant derivatives of camptothecin analogs, and nanometer-sized camptothecin prodrugs are also provided.

Antioxidant camptothecin derivatives and antioxidant antineoplastic nanospheres thereof

This invention relates to compositions and methods utilizing a chemotherapeutic drug and 6-bromoindirubin3'-oxime (BIO) for the treatment of cancer, including glioblastoma multiforme. The present invention demonstrates that BIO works synergistically with chemotherapeutic drugs to increase the cytotoxic effects of these drugs in glioma cells.

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Los Angeles, CA, United States of America

John S Yu