Inhale Therapeutic Systems, Inc.

Nektar Therapeutics

Dance Biopharm Inc.

Aerami Therapeutics, Inc.

Novartis Ag

Novartis Pharma Ag

Naktar Therapeutics

Mektar Therapeutics

John S Patton

Robert M Platz

Mohammed Eljamal

Mei-chang Kuo

Linda C Foster

Ryan S Patton

Yehuda Ivri

Linda S Foster

Blaine Bueche

Mohammad Eljamal

J Milton Harris

David B Bennett

Chester Leach

Kimberly Perkins

Matthew Sander

David Lechuga-Ballesteros

Jim Fink

Lisa Molloy

Kirsten M Cabot

Ronald Keith Wolff

Benjamin Lee Hughes

Hi-Shi Chiang

Geraldine Venthoye

Darrel LaVern Allen

Sudha Nagarajan

Joanne Greene

Cheryl L M Stults

Mary Stiff-Torvik

William David Roeder

Michael T Newhouse

Trixie K Tan

An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

Preservative-free single dose inhaler systems

A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler.

Methods and systems for supplying aerosolization devices with liquid medicaments

Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.

Liquid insulin formulations and methods relating thereto

One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.

Preservative free insulin formulations

A dispenser for supplying a metered volume of a liquid medicament to an aerosolizing device. The dispenser may include a container having a proximal end and a distal end, wherein the container is configured to store a volume of liquid medicament. The dispenser may also include a dispensing mechanism coupled to the distal end of the container. The dispensing mechanism may have a distal end terminating in a tip through which the liquid medicament is dispensed. The dispensing mechanism operates to dispense a metered volume of the liquid medicament from the tip each time the dispensing mechanism is operated. The distal end of the dispensing mechanism includes an interface that interacts with a housing of an inhaler to limit an insertion depth of the tip into an opening the housing.

Liquid dispensing and methods for dispensing liquids

Preservative-free single dose inhaler system

One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.

Preservative free insulin formulations and systems and methods for aerosolizing

An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

An aerosolization device comprises a chamber adapted to contain a powder pharmaceutical formulation, a lid at least partially covering the chamber, at least one piercing element forcible through the lid to provide access to the powder pharmaceutical formulation, and a shapeable surface extending from the chamber, the shapeable surface being adapted to undergo a shape change to form a conduit. The powder pharmaceutical formulation may be extracted from the chamber by a user inhaling through the conduit. In another version, the lid is removable from the chamber without the need for a piercing element.

Powder aerosolization apparatus and method

Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs.

Methods and compositions for pulmonary delivery of insulin

Growing community of inventors

Portola Valley, CA, United States of America

John S Patton