Imperial Chemical Industries Limited

John S Morley

Christopher F Hayward

Anand Swaroop Dutta

Gilbert J Stacey

James J Gormley

Alan F Hawkins

Terence R Owen

Nigel N Petter

Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 stand for alk-2-enyl radicals of not more than 6 carbon atoms, A stands for Gly or Azgly, B stands for Leu or Met, J stands for --(CH.sub.2).sub.n --, wherein n stands for an integer from 1 to 10, or a phenylene radical, and pharmaceutically-acceptable acid-addition salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are selective .delta.-opiate-receptor antagonists.

Dimers of peptide amides

The disclosure relates to novel polypeptides which possess analgesic activity, to processes for their manufacture and to pharmaceutical compositions containing them. Typical of the peptides disclosed is: ##STR1##

Polypeptide

This invention provides a method of enhancing, or preventing the decline in, the digestibility of a crop, in particular of a fodder crop, by applying to the crop, to seed of the crop, or to the locus of the crop or seed, a compound or a mixture of at least two compounds of general formula (I) ##STR1## wherein R is hydrogen or --COR.sup.1 wherein R.sup.1 is alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkyloxy, X is --O--, --NE-- or --CH.sub.2 --, Y is carboxy or an alkali metal, ammonium or mono- or di-alkyl- or cycloalkylamine salt thereof, or Y is alkoxycarbonyl, aryloxycarbonyl, aralkyloxy- carbonyl, amino or mono- or di-alkyl- or aryl- amino, Z is hydrogen, halogen, nitro, alkyl, trihalomethyl, hydroxy, alkoxy, acyloxy, cyano or alkylenedioxy, and x is an integer of 1 to 3. The invention also provides novel compounds, namely L-.alpha.-aminooxy-.beta.-(parahydroxy phenyl) propionic acid, and acid addition salts thereof.

Method of improving or maintaining digestibility of fodder crops

The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is

Growing community of inventors

Macclesfield, United Kingdom

John S Morley