Phyton Holdings, LLC

Natural Pharmaceuticals, Inc.

Natural Pharmaccuticals, Inc.

John S Juchum

Rex T Gallagher

James Harvey Johnson

Roland R Franke

Dong S Yang

Brian A Bucher

Christopher D Howe

Barry Joseph Hand

Edward M Desimone, Iii

Marc A Plante

T G Sambandam

James H Johnson

Edward M Desimone

Dasheng Wang

T G Sambandan

James A Johnson

Tg Sambandam

Barry J Haad

Marc A Plant

Edward M De Simone, Iii

Rex T Gallegher

Edward M Iii Desimone

A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.

Purification of taxanes

Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.

Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.

This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins

The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.

Methods and compositions for converting taxane amides to paclitaxel or other taxanes

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Kingston, NH, United States of America

John S Juchum