Durect Corporation

John S Dinka

Edward M Gillis

James A Filice

Peter Wickman

John Culwell

Felix T Theeuwes

Andrew I Poutiatine

James E Brown

Barbara F Laidlaw

Randolph Mellus Johnson

Dana Litmanovitz

Andrew L Poutiatine

Su-Il Yum

Implantable delivery devices () for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir () for storing the agent, a driving means for driving the agent from the reservoir () and a valving and control mechanism () which is positively actuatable between a closed configuration and an open configuration.

Device and method for accurate delivery of an active agent

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners

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Fairfax Station, VA, United States of America

John S Dinka