Schering Corporation

John S Abrams

Frank D Lee

Isabelle Chretien

Chuan-Chu Chou

Nicholas J Murgolo

Paul J Zavodny

William T Windsor

Stephen Tindall

Chung-Her Jenh

Mary E Petro

Jon E Silver

Ken-ichi Arai

Takashi Yokota

Robert E Van Dyke

Michael K Pearce

A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.

Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5

Humanized monoclonal antibodies against human interleukin-5

Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4.

Monoclonal antibodies against human interleukin-4 and hybridomas

Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.

Human interleukin immunopurification processes

Monoclonal antibodies and compositions thereof are provided for detecting, measuring, and immunopurifying human GM-CSF.

Immunochemical assay for human granulocyte-macrophage colony stimulating

Peptides derived from human interleukin-4 are provided comprising from 6 to 40 amino acids. Conjugates of the peptides and carriers are also provided for the production of polyclonal and/or monoclonal antisera to human interleukin-4.

Human interleukin-4 peptides and conjugates thereof

Growing community of inventors

Belmont, CA, United States of America

John S Abrams