Massachusetts Eye and Ear Infirmary

Harvard College

Worcester Polytechnic Institute

The General Hospital Corporation

John Rosowski

Saumil N Merchant

Jennifer Ann Lewis

Cosme Furlong

Michael J McKenna

David B Kolesky

Mark Andrew Skylar-Scott

Daniel J Lee

Aaron K Remenschneider

Nicole Black

Alexander D Valentine

Guillermo J Tearney

Brett Eugene Bouma

Dvir Yelin

Elliott Kozin

Elliot Kozin

Michael J Mckenna

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a 'lock and key' manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.

Artificial tympanic membrane devices and uses

Methods and systems for endoscopic observation of tympanic function.

Methods and systems for observation of tympanic function

An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.

Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy

Growing community of inventors

Arlington, MA, United States of America

John Rosowski