Interleukin Genetics, Inc.

Orig3n, Inc.

John Rogus

Gordon W Duff

Kenneth S Kornman

Kenneth M Huttner

Xiaodong Wu

Hwa-Ying Wang

Leon Wilkins

Hong Min Chen

An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

Method for determining severity and progression of periodontal disease

The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster&#x2014;including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus&#x2014;which contains the previously-identified IL-1&#x3b1;, EL-1&#x3b2; and IL-IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-I haplotype associated inflammatory phenotypes.

IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes

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North Andover, MA, United States of America

John Rogus