Smithkline Beecham Corporation

Human Genome Sciences, Inc.

Other

John Richard White

Jerry Leroy Adams

Haodong Li

Timothy Francis Gallagher

Edward Robert Appelbaum

John C Lee

Mark D Adams

Ralph Froman Alderson

David M Parmelee

Yuling Li

Louis Martin Pelus

Henrik S Olsen

Solange H L Gentz

Katherine L Widdowson

Dashyant Dhanak

Henry M Sarau

Solange Hanschke Lima

Brendt L Kreider

Solange H Gentz

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Antibodies to MCP-4

Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Human chemokine beta-10 mutant polypeptides

Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.

Method of mobilizing stem cells with chemokine &bgr;-8

Antibodies to human CK&bgr;-10/MCP-4

Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Compounds

Phenylalanine sulfonamide derivatives and their use as CCR-3 receptor antagonist.

CCR-3 receptor antagonists

The invention relates to the method of preventing and treating sepsis and ARDS using chemokine &bgr;-4 or a biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Method of treating sepsis and ARDS with chemokine &bgr;-4

The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Method of treating sepsis and ARDS using chamohine beta-10

Disclosed are methods for discovering agonists and antagonists of the interaction between a secreted human protein, chemokine CK.beta.-9, and its cellular receptor, human CCR7, which may have utility in the treatment of several human diseases, including, but not limited to: allergic disorders, autoimmune diseases, ischemia/reperfusion injury, development of atherosclerotic plaques, cancer (including mobilization of hematopoietic stem cells for use in chemotherapy or mycloprotection during chemotherapy), chronic inflammatory disorders, chronic rejection of transplanted organs or tissue grafts, chronic myelogenous leukemia, and infection by HIV and other pathogens.

Methods of screening for agonists and antagonists for human CCR7

Pyrimidinyl imidazoles

Imidazole derivatives and their use as cytokine inhibitors

Pyridyl imidazoles

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Coatesville, PA, United States of America

John Richard White