Campina Nederland Holding B.v.

John Richard Langridge

Linqiu Cao

Alexander Wilhelmus Van Gessel

A controlled release excipient composition suitable in formulation of a slow or extended release tablet, contains a synergistic mixture of substantially uncross-linked carboxymethyl starch, or sodium starch glycolate (SSG), and a hydrophilic, non-ionic cellulose ether, preferably hydroxypropylmethylcellulose. Whether or not a SSG in the mixture is sufficiently uncross-linked in the context of the invention can be determined by sedimentation: 0.25 g of the formulation in 100 ml deionized water after 24 hours at 25&#xb0; C., if subjected to centrifugation at 6080 G at 25&#xb0; C. for 15 minutes, should exhibit a sedimentation volume of more than 60 ml.

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Sint Oedenrode, Netherlands

John Richard Langridge