Exemplar Genetics LLC

Boehringer Ingelheim Vetmedica Gmbh

John Randall Swart

Christopher S Rogers

Eric Martin Vaughn

Michael B Roof

Phillip Wayne Hayes

Karen E Freking

Reid C Phillips

The present invention provides transgenic, large non-human animal models of atherosclerosis and hypercholesterolemia, as well as methods of using such animal models in the identification and characterization of therapies for atherosclerosis and hypercholesterolemia.

Animal models of atherosclerosis

The present invention provides transgenic, large non-human animal models of Duchenne muscular dystrophy, Becker muscular dystrophy, and DMD-associated dilated cardiomyopathy, as well as methods of using such animal models in the identification and characterization of therapies for Duchenne muscular dystrophy, Becker muscular dystrophy, and DMD-associated dilated cardiomyopathy.

Animal models of duchenne muscular dystrophy

The present invention provides transgenic, large non-human animal models of cancer, as well as methods of using such animal models in the identification and characterization of therapies for cancer.

Animal models of cancer

The present invention provides a composition and an improved single dose vaccine againstand an improved single dose vaccine againstandwhich provides one or more of the following: 1) confers effective immunity againstand/or; 2) decreases the risk of developing clinical signs ofand/orinfection; 3) induces an immune response againstand/or; and 4) has a DOI againstand/orof at least four months. The composition orvaccine as well as the combined-composition or vaccine each includes a bacterial component of inactivatedbacteria and a suitable adjuvant. The combined-composition or vaccine further includes an amount ofantigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount ofand/orantigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting fromand/orinfection for a suitable duration of immunity.

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Orange City, IA, United States of America

John Randall Swart