The Scripps Research Institute

University of California

John R Teijaro

Benjamin F Cravatt

Robert M Krug

Megan Blewett

Ethan Bier

Keriann M Backus

Michael Oldstone

Bruno E Correia

Meghana Malur

Margery Smelkinson

Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.

Cysteine reactive probes and uses thereof

Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the Bone Morphogenetic Protein (BMP), the Notch (N) signaling pathways or combinations thereof, which activity is altered by the viral protein NS1. The method and composition comprise use of a compound that modulates at least one of these essential host signaling pathways for preventing or controlling symptoms associated with influenza viral infection. The method or composition can also be used either alone or in combination with other therapeutic agents for treating or protecting against influenza infection, and associated syndromes.

Protection and treatment against influenza infection

Growing community of inventors

San Diego, CA, United States of America

John R Teijaro