Hsc Research Development Corporation

Other

University of Michigan

Hsc Research and Development Limited Partnership

The Board of Regents Acting for and on Behalf of the University of

John R Riordan

Johanna Rommens

Francis S Collins

Manuel Buchwald

Mitchell L Drumm

Michael C Iannuzzi

Bat-Sheva Kerem

Lap-Chee Tsui

Tsui Lap-Chee

Canhui Li

Mohabir Ramjeesingh

Christine E Bear

The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.

Cystic fibrosis gene

Methods of detecting cystic fibrosis gene by nucleic acid hybridization

Cystic fibrosis transmembrane conductance regulator (CFTR) protein

A method for isolating a cDNA specific for P-glycoprotein is disclosed. The P-glycoprotein is the determinant in the multidrug resistance phenotype exhibited by living cells. The nucleic acid equivalent of the cDNA may be cloned in a recombinant plasmid or phage. The cDNA may also be used as a probe in determining multidrug resistance in cells. The DNA molecules specific for the P-glycoprotein is in the form of a gene family where various members of the gene family are amplified to varying degrees in multidrug resistant cells from various sources.

Multidrug resistance in mammalian cell lines and isolation of

Growing community of inventors

Toronto, Canada

John R Riordan