Bristol-myers Squibb Compnay

Bristol-myers Company

Mead Johnson Nutrition Company

John R Reckelhoff

Claude E Gallian

Robert J Bequette

Bruce A Bonenberger

John R Euber

Joshua C Anthony

Win-Chin Chiang

Khaled A Khatib

Robert A Burns

Yung H Lee

The present invention relates to an amino acid-based nutritional formulation comprising, per 100 g total amino acids, between about 4.5 and about 5 g glutamate. The ratio of cysteine:methionine is in the range of about 0.9:1 to about 1:1.2. The nutritional formulation may also comprise a lipid source, a carbohydrate source, an emulsifier comprising CITREM or DATEM, and amino acids, wherein glutamate is present in an amount of between about 4.5 and about 5 g per 100 g total amino acids.

Amino acid-based nutritional formulations

A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.

Direct compression cholestyramine tablet and solvent-free coating

Direct compression cholestyramine tablet and solvent-free coating thereof

Growing community of inventors

Evansville, IN, United States of America

John R Reckelhoff