Duke University

The University of North Carolina at Chapel Hill

Georgia State University Research Foundation, Inc.

Other

Auburn University

John R Perfect

Richard Ray Tidwell

David W Boykin

W David Wilson

Christine C Dykstra

Chad F Stephens

James E Hall

Byron L Blagburn

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R, R, Rand Rare each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; Ris H, alkyl or aryl; Ris H, alkyl, aryl, or NRR, in which Rand Rare each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR, in which Ris H or alkyl, and to the use of such compounds.

Synthesis and antimicrobial activity of novel dicationic 'reversed amidines'

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R, R, Rand Rare each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; Ris H, alkyl or aryl; Ris H, alkyl, aryl, or NRR, in which Rand Rare each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR, in which Ris H or alkyl, and to the use of such compounds.

Synthesis and antimicrobial activity of novel dicationic &ldquo;reversed amidines&rdquo;

Methods of treating fungal infections comprise administering a therapeutically effective amount of a compound described by Formulas &lsqb;(I)-(VI)&rsqb;. Examples of fungal infections include,and combinations thereof.

Antifungal activity of dicationic molecules

The present invention provides methods for treating,and,in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.

Methods of combatting infectious diseases using dicationic bis-benzimidazoles

The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.

Methods of combating infectious diseases using dicatoni

Methods of combatting infectious diseases using dicationic

Method of combatting infectious diseases using dicationic

Methods of combatting infectious disease using dicationic

Method of combatting infectious diseases using dicatonic

The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or ##STR2## wherein: each R.sub.2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.2 groups together represent C.sub.2 -C.sub.10 alkylene, or two R.sub.2 groups together represent ##STR3## wherein m is from 1-3 and R.sub.4 is H, ##STR4## or --CONHR.sub.5 NR.sub.6 R.sub.7, wherein

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Durham, NC, United States of America

John R Perfect