Alza Corporation

Intarcia Therapeutics, Inc.

Other

John R. Peery

James B. Eckenhoff

Jeremy C. Wright

Frederick H. Maruyama

James E. Brown

Scott J. Gilbert

John R Peery

James B Eckenhoff

Judy A Magruder

Jeremy C Wright

Richard Lewis Cortese

Felix A Landrau

Keith E Dionne

Scott D Lautenbach

James B Pike

Jonathan P Smith

Craig R Davis

Urano A Robinson

James B Eckenhoff, Deceased

J Richard Gyory

Lyle Elmore Ziemann

Houdin Dehnad

Frederick H Maruyama

Fred H Maruyama

Lawton Hom

Lewis L Peterson

Kevin S Ly

Virgil A Place

Peter F Carpenter

Bonnie J Eckenhoff, Legal Representative

Edward V Bourneuf

John M Sharockman

William K Griesinger

Gary A Lattin

Harold M Leeper

Mark R Bilitz

Scott Jay Gilbert

James E Brown

Jack Gorby

Michael N Gold

Robert Mosbauer

Bonnie J Eckenhoff

Ed Bourneuf

Gary A Messer

Nikki Baumrind

Saadia M Schorr

J Richard Gory

Scott J Gilbert

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

Sustained delivery of an active agent using an implantable system

An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.

Osmotic delivery system flow modulator apparatus and method

An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trauma and tearing of tissue during implant insertion. A spring element received within the cannula prevents an implant which is to be inserted into an animal from falling out of the cannula during the implant insertion process. The spring element includes a longitudinal leg which is folded with a zigzag-shaped bend. When the spring element is inserted into the cannula, the zigzag-shaped bend of the longitudinal leg retains the implant within the cannula.

Trocar for inserting implants

The present invention includes an osmotic pump that includes a means for venting an osmotic composition included in the pump before the internal pressure of the pump has the opportunity to build to such an extent that the pump is structurally compromised, such as when one or more components of the pump are physically separated. The means for venting osmotic material included in an osmotic pump according to the present invention includes a vent that allows the material included in the osmotic composition of the pump to dissipate into an environment of operation at a rate that results in dissipation of the pressure created within the osmotic pump and a reduced potential for subject discomfort or irritation.

Osmotic pump with means for dissipating internal pressure

An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i.e., die-cutting, stamping or otherwise cutting to shape) to provide a uniform nonribbed membrane material. The capsule also includes a membrane material-retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.

Osmotic implant with membrane and membrane retention means

An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trama and tearing of tissue during implant insertion. A spring element received within the cannula prevents an implant which is to be inserted into an animal from falling out of the cannula during the implant insertion process. The spring element includes a longitudinal leg which is folded with a zig-zag shaped bend. When the spring element is inserted into the cannula the zig-zag shaped bend of the longitudinal leg retains the implant within the cannula.

Electrotransport system having flexible means

Growing community of inventors

Stanford, CA, United States of America

John R Peery