Terumo Bct, Inc.

Caridianbct, Inc.

John R Lindner

Jeremy P Kolenbrander

William Sweat

James R Ladtkow

Jeffrey A Steward

William G Palsulich

Christopher Fletcher

Aditya Dalvi

Dave Tyler

Dave Gibbons

David Gibbons

Jennifer Hinz

Joseph Scibona

Jennifer Wheeler

William Palsulich

A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.

System for blood separation with replacement fluid apparatus and method

A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of 'spoiling' the image, 'diffusing' the image, &#x201c;edge detection&#x201d;, &#x201c;edge linking&#x201d;, &#x201c;region-based confirmation&#x201d;, and &#x201c;interface calculation&#x201d;. &#x201c;Spoiling&#x201d; reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. &#x201c;Diffusing&#x201d; smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. &#x201c;Edge detection&#x201d; computes the rate of change in pixel intensity. &#x201c;Edge linking&#x201d; connects adjacent maxima. &#x201c;Region-based confirmation&#x201d; creates a pseudo image of the regions that qualify as distinct. &#x201c;Final edge calculation&#x201d; uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

Blood processing apparatus with robust automated process control

A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.

Blood processing apparatus with controlled cell capture chamber trigger

An extracorporeal blood processing system having a centrifugal rotor, a control system, a plurality of peristaltic pumps, and a removable tubing circuit wherein blood components can be processed. A pump-balancing process, implemented by the control system, causes selected pumps to fill and empty a reservoir in the tubing circuit. Ratios of displaced volume per pump revolution or other pumping action can be used by the control system to increase the effectiveness and efficiency of the donation process. The pump-balancing process may be performed during priming or set-up of the blood processing system or during an actual donation.

Extracorporeal blood processing apparatus with pump balancing

Growing community of inventors

Morrison, CO, United States of America

John R Lindner