Smithkline Corporation

Other

Smith Kline & French Laboratories Limited

On Target Enterprises, Inc.

John R Hoover

Jerry Arnold Weisbach

George L Dunn

Robert M De Marinis

Robert M DeMarinis

David J Cooper

Timothy Yu-Wen Jen

Provided is a non-transitory machine readable medium on which is stored a computer program including instructions to adapt a computer system having at least one processor as a simultaneous radio detection and bearing system, including: an RF conditioning subsystem for connection to a plurality of arrays of Frequency Range signal receiving channels, the RF conditioning subsystem operable to combine the signals from the arrays as a first internal data stream; and a coherent multi-channel digitizer subsystem coupled to the RF conditioning system, the coherent multi-channel digitizer subsystem operable to generate a time domain snapshot of the first internal data stream. The computer instructions further adapting the processor to transform the time domain snapshot to a frequency spectrum and identify at least one signal above a threshold at a determined frequency, determine the bearing of the signal, and provide the determined frequency of a selected identified signal to an audio recording subsystem, the audio subsystem contemporaneously recording the selected signal upon the determined frequency.

Simultaneous radio detection and bearing system

Provided is a simultaneous radio detection and bearing system. More specifically, the radio detection and bearing system includes an RF conditioning subsystem having a plurality of First Frequency Range and Second Frequency Range signal receiving channels. The RF conditioning subsystem operable to combine First Frequency Range and Second Frequency Range signals as a first internal data stream. A coherent multi-channel digitizer subsystem is coupled to the RF conditioning system, the coherent multi-channel digitizer subsystem operable to generate a time domain snapshot of the first internal data stream. An audio recording subsystem is also coupled to the RF conditioning subsystem. A processor is coupled to the coherent multi-channel digitizer subsystem and the audio recording subsystem. The processor is operable to transform the time domain snapshot to a frequency spectrum and identify at least one signal above a threshold at a determined frequency, determine the bearing of the signal, and provide the determined frequency to the audio recording subsystem. The audio subsystem contemporaneously records the signal upon the determined frequency. An associated method of radio detection and bearing determination is also provided.

Cephalosporin compounds substituted in the 7-position with a hydroxy-halo substituted .alpha.-aminophenylacetamido group and in the 3-position with a heterocyclicthiomethyl group are prepared by 7-acylation. The products are antibacterial agents.

7-Hydroxyhalophenylacetamido-3-heterocyclicthiomethyl cephalosporins

Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.

Protected .alpha.-amino-.alpha.-ureido(thioureido)phenylacetic acids

.alpha.-AMINO-.alpha.-(UREIDOPHENYL)ACETAMIDOCEPHALOSPORINS AND THEIR

Alpha-amino-alpha-(ureidophenyl)acetamidocephalosporins and their

Pharmaceutical compositions of

Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as intermediates to pseudotrisaccharides.

Mercaptopseudotrisaccharides

.alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins

7-(p-Hydroxymethylphenylglycylamido)cephalosporins are prepared by acylating a 7-aminocephalosporin compound. The products have antibacterial activity.

P-Hydroxymethylphenylacetamidocephalosporins

Cephalosporin compounds substituted at the 7-position with free or substituted .alpha.-amino or hydroxy phenylacetamido and at the 3-position with a heterocyclic thiomethyl group are prepared by displacement of a 3-acetoxymethyl compound with a mercaptoheterocycle or by 7-acylation. The products are antibacterial agents.

3-Heterocyclic thiomethylcephalosporins

Novel 7-oxocephalosporins and a process for preparing them are disclosed. These compounds are useful intermediates in the preparation of other cephalosporins which have antibacterial activity.

Cephalosporin intermediates and process therefor

p-Hydroxymethylphenylglycine

Cephalosporin compounds substituted at the 7-position with free or substituted .alpha.-aminophenylacetamido and at the 3-position with a heterocyclic thiomethyl group are prepared by displacement of a 3-acetoxymethyl compound with a mercaptoheterocycle. The products are antibacterial agents.

3-Heterocyclic thiomethylcephalosporins as antibacterial agents

Esters of 7-trifluoromethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-c ephem-4-carboxylic acid are prepared. These compounds are antibacterial agents.

Growing community of inventors

Glenside, PA, United States of America

John R Hoover