Merial Sas

Other

Merial Limited

Centralsquare Technologies, LLC

John R Harding

Catherine Elisabeth Charreyre

Gilles Emile Chappuis

John Ellis

Brian Martin Meehan

Edward Clark

Lori Hassard

Deborah Haines

Francis McNeilly

Gordon Moore Allan

Andrew A Potter

Lorne A Babiuk

Philip J Willson

Li Wang

Jean-Christophe Francis Audonnet

Ryan Sealy

Erik Cooley

Nathan Daniels

Ryan Neil McAlister

Andrew Horlacher

Brian Taylor

George Krakowka

Jonathan K Wesley, Sr

Ronald Michael Green

Jonathan Wesley

Alicemarie G Rathjen

Jacquelyn C Appell Wheeler

Xavier Thomas

Keith A Dieterich

Lois S Harding

William Kimmerly

Jack L Strauss

Alex Fordyce

Gordon Allan Moore

George Steve Krakowka

Systems and methods for dynamically integrating disparate computer-aided dispatch (CAD) systems are disclosed. The systems and methods provide bi-directional interoperability between disparate CAD systems and maintain stateful ongoing interactions between interconnected CAD systems. Information objects in one CAD system are associated and bound to related objects in other CAD systems through a centralized information hub that transforms data items intelligently to facilitate communication and interaction between the CAD systems connected to the hub. The described systems and methods maintain complete and current perspectives of all relevant information for each CAD system connected to the information hub, thereby eliminating the need for point-to-point intelligence maintained by the CAD systems about the other interconnected CAD systems. As information updates are passed from CAD systems to the information hub and back out to other CAD systems, the information hub transforms and evaluates the information updates ensuring that only necessary information updates are forwarded.

Dynamically integrated disparate computer-aided dispatch systems

Dynamically integrating disparate computer-aided dispatch systems

The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

Postweaning multisystemic wasting syndrome and porcine circovirus from pigs

Provided is a method for reducing viral load of porcine circovirus type 2 (PCV-2) in a pig by inducing an immune response against PCV-2 through the administration of an immunogenic composition comprising a PCV-2 antigen. A preferred antigen is a vector containing a PCV-2 nucleotide sequence. In a particularly preferred embodiment, the PCV-2 nucleotide sequence is ORF4, ORF13, or ORF4 and ORF13. In some embodiments, the immunogenic composition includes one or more additional pig pathogens.

Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2

The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuated or inactivated vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as reagents and diagnostic methods. It also relates to the DNA fragments which can be used for the production of subunits in an in vitro expression vector or as sequences to be integrated into a virus or plasmid type in vivo expression vector.

Porcine circoviruses, vaccines and diagnostic reagents

Method and system for preparing a personal genetic profile includes collecting genetic data from an individual, assigning the data to a coordinate system, storing the data, and providing access for retrieval by the individual from whom the genetic data were collected, after receipt of an Identifier that adequately authenticates the identity of the data requester. Locations of genetic markers are provided as three-dimensional coordinates, described with matrix relationships that are consistent with the primary and secondary chemical structure of molecular constituents of a DNA chain for the individual.

Method for preparing and using personal and genetic profiles

Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6 and 8 and/or the 10 and 13 weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.

Reduction of porcine circovirus-2 viral load with inactivated PCV-2

Porcine circoviruses vaccines diagnostic reagents

Porcine circovirus vaccine and diagnostics reagents

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San Francisco, CA, United States of America

John R Harding