Other

University Hospitals Cleveland Medical Center

Case Western Reserve University

University Radiologists, Inc.

John R Haaga

Rebecca Haaga

Jeffrey L Duerk

Jonathan S Lewin

Agata A Exner

Tianyi Krupka

Brent Weinberg

Joseph P Molter

David A Miller

Michael P Cody

Ashley Davidoff

The present invention relates to a pharmaceutical cocktail and methods of cancer treatment. In particular, one such cocktail comprises a combination of effective amounts of a lactate transporter inhibitor, a carbonic anhydrase inhibitor, a sodium potassium chloride cofactor (NKCC) transporter inhibitor, a member of the hydroxycinnamate class of drugs or a derivative thereof, and/or an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab in combination with blood vessel occlusion. As most cancers in an untreated state uses both aerobic and anaerobic/glycolytic pathways treatments contemplated herein can affect both metabolic pathways.

Targeted treatment of anerobic cancer

The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and methods of treating cancer involving effective amounts of a carbonic anhydrase inhibitor. Pharmaceutical compositions and methods of treating cancer (eliminating the tumor, shrinking the tumor, prolonging the life of the patient, increasing quality of life by decreasing the grade of adverse events seen with other cancer treatments, and/or preventing/reducing the likelihood of the tumor's metastases) are additional aspects of the present invention. In addition, the present invention may be used to favorably impact the therapeutic result of patients who have not responded to alternative, traditional anti-cancer therapy.

A method for treating a neoplastic disorder in a subject includes administering to the neoplastic cells a neoplastic cell-sensitizing composition including a poly(ethylene oxide)-poly(propylene oxide) copolymer. The poly(ethylene oxide)-poly(propylene oxide) copolymer can sensitize the neoplastic cells to hyperthermia. Energy can be applied to the neoplastic cells to heat and ablate the cells.

Method for treating a neoplastic disorder

Safety apparel and/or non-apparel items that filter from the air one or more airborne particles and/or undesired gasses to provide safety to a human and/or non-human from potentially unhealthy airborne particles. The apparel and/or non-apparel item at least partially includes a filter material. The filter material on the apparel and/or non-apparel item has a sufficient size to enable the human and/or non-human to cover the nose, eyes, and/or mouth of the human and/or non-human. The filter material filters at least one airborne particle and/or undesired gas by a mechanical mechanism, an electrical mechanism, and/or a chemical mechanism. The apparel and/or non-apparel item can include at least one visual and/or textural indicator on the apparel and/or non-apparel item to at least partially indicate the location of the filter material on the apparel and/or non-apparel item.

Safety filtration apparel

Safety apparel and/or non-apparel items that filter from the air one or more airborne particles and/or undesired gases to provide safety to a human and/or non-human from potentially unhealthy airborne particles. The apparel and/or non-apparel item at least partially includes a filter material. The filter material on the apparel and/or non-apparel item has a sufficient size to enable the human and/or non-human to cover the nose, eyes, and/or mouth of the human and/or non-human. The filter material filters at least one airborne particle and/or undesired gas by a mechanical mechanism, an electrical mechanism, and/or a chemical mechanism. The apparel and/or non-apparel item can include at least one visual and/or textural indicator on the apparel and/or non-apparel item to at least partially indicate the location of the filter material on the apparel and/or non-apparel item.

A cargo delivery device has coaxial, telescopically interengaged cargo delivery needle, an outer cannulas which are axially and rotatably displaceable relative to one another. The cargo delivery needle has a distal portion provided with a cargo recess for carrying a cargo to a site in a patient.

Cargo delivery needle

A method and device for generating a forensic skull and soft tissue database used for the on-line facial reconstruction of victims and age progression portrait rendering of missing children through utilization of advance diagnostic radiologic modalities.

Forensic skull and soft tissue database and on-line facial

A biopsy needle has coaxial, telescopically interengaged stylet, inner and outer cannulas which are axially and rotatably displaceable relative to one another. The stylet has a distal portion provided with a cutting recess for severing a biopsy specimen from a site in a patient, and the inner cannula has a distal portion for cutting and capturing the specimen in the recess for removal from the site upon withdrawal of the needle from the patient. The distal portion of the inner cannula is partially cut away to provide an insert recess which supports a semi-circular insert of hemostatic collagen which remains at the site upon removal of the needle to minimize hemorrhagic complications by promoting blood clotting. The insert and the distal portion of the inner cannula have radially outer surfaces of corresponding radius whereby the distal portion of the inner cannula and the insert supported thereon are received within the distal end of the outer cannula prior to use of the needle.

Biopsy needle

A tubular sheath is disclosed which is slidably disposed over a tubular medical device which tubular medical device is positioned at a body tissue access site. The sheath is deposited within a patient to assist in sealing the incision caused by the tubular medical device and inhibit internal and external bleeding. The sheath includes a generally rigid outer coating and an absorbable and expandable inner core, which when positioned, in situ, at the accessed opening of the patient's body part can function as a vascular plug.

Sheath for wound closure caused by a medical tubular device

Biopxy system with hemostatic insert

An improved, cone shaped puncturing/cutting tip is provided for the inner cannula or alternative, the stylet, of a biopsy needle. The cone shaped tip is defined by a frontal vertex co-incident with the center of the cannula or the stylet and a circular base of diameter about equal that of the cannula or stylet. The surface of the cone shaped tip end includes at least three circumferentially spaced, longitudinally extending cutting vane edges extending from the vertex to the base and is hollowed between adjacent vane cutting edges whereby cutting penetration of said tip to the site is enhanced without significant vertex deflection of the point during penetration.

Cutting tip for biopsy needle

A stylet for a biopsy needle is provided with a specimen recess inwardly of the distal end thereof which has a bottom wall parallel to the axis of the stylet and distal and proximal end walls which are reentrant relative to the distal end and proximal position of the stylet, respectively.

Growing community of inventors

Chagrin Falls, OH, United States of America

John R Haaga