The University of Tennessee Research Foundation

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John R Flaherty

Tse-Wei Wang

John Douglas Birdwell

Mark S Rader

Xue Ning

Ning Xue

Bradley P Gehring

Least Square Deconvolution (LSD) uses quantitative allele peak data, for example, allele peak area, allele peak height and optical density, derived/obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.

Least-square deconvolution (LSD): a method to resolve DNA mixtures

Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.

Least Square Deconvolution (LSD) uses quantitative allele peak area derived from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.

Least-Square Deconvolution (LSD): a method to resolve DNA mixtures

An apparatus and method for drying and deagglomerating substances of finely-divided solids suspended in a fluid medium. The apparatus includes the basic components of a phenumatic friction dryer, a flash dryer and a ring dryer.

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Philadelphia, PA, United States of America

John R Flaherty