Pfizer Corporation

John R Cardinal

Scott Max Herbig

Kelly L Smith

Richard W Korsmeyer

Avinash G Thombre

Jeelin Lo

William John Curatolo

Charles D Ebert

A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

Asymmetric membranes in delivery devices

Use of asymmetric membranes in delivery devices

Compositions for the controlled and prolonged release of macromolecular compounds comprise a porous matrix of chitosan having dispersed therein the macromolecular compound. Examples of macromolecules used in the composition are pharmacologically active ones such as peptide hormones, e.g. growth hormone.

Chitosan compositions for controlled and prolonged release of

Laminate device for the controlled and prolonged release of at least one active agent to an ambient environment comprising at least one core sheet, said core sheet or sheets comprising said agent or agents in a polymer matrix, and, in a preferred embodiment, a porosity enhancing agent in admixture with said agent; said core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. In a modification of said device the perimeter edge thereof is coated by an inert polymeric film substantially impermeable to said environment and to said agent or agents. Also included are methods for making such a device.

Laminate device for controlled and prolonged release of substances to an

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Old Lyme, CT, United States of America

John R Cardinal