Rti Biologics, Inc.

Rti Surgical, Inc.

Regeneration Technologies, Inc.

Warsaw Orthopedic, Inc.

Other

Sdgi Holdings, Inc.

John R Bianchi

C Randal Mills

Wesley I Lewis

Kevin C Carter

Chandrasekaran Nataraj

Joe Kutsavage

Michael R Roberts

David T Cheung

John W Howell, Jr

Arunas A Zhukauskas

Bradley T Estes

John A Pafford

Todd E Goede

Larry G Boyd

Lauren M Brown

Jamie M Grooms

Guy B Grover

Dayna Buskirk

Michael Esch

Ben R Sanders

P J Gorham

Pat Coleman

Kevin Ross

Angela Carr

John F Wironen

Daniel Urbaniak

Sean Hanstke

Russell S Donda

Glenn C Klein

Thomas W Sander

Harry Rambo

Zhukauskas A Arunas

Harry W Rambo

Darren G Jones

Dan Urbaniak

Raymond E Olsen

Michael J Zingaro

Benjamin R Sanders

The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.

Connective-tissue-based or dermal-tissue-based grafts/implants

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

Assembled implant

The present invention has multiple aspects relating to a bone-tendon-bone graft and components thereof. Embodiments of the present invention comprise an intermediate bone block that is used to adjustably secure soft tissue (e.g., tendon) in a patient. The present invention further relates to an assembled bone-tendon-bone graft suitable for implantation in humans comprising the intermediate bone block and a length of soft tissue. In a preferred embodiment, a bone-tendon-bone graft comprises a length of soft tissue (e.g., tendon) extending from a first assembled bone block to a second bone block and then doubles back to said first assembled bone block. Depending upon the embodiment, the second bone block fixedly or slideably attaches to the length of soft tissue and facilitates it doubling back to the first assembled bone block.

Adjustable and fixed assembled bone-tendon-bone graft

The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.

Muscle-based grafts/implants

The present invention relates to a bone-tendon-bone graft and components. Embodiments of the present invention comprise an intermediate bone block that is used to adjustably secure soft tissue (e.g., tendon) in a patient. Embodiments of intermediate bone blocks of the present invention are used singly or in combination with one or more bone blocks to form a bone block assembly for securing soft tissue. The present invention further relates to an assembled bone-tendon-bone graft for implantation in humans comprising the intermediate bone block and a length of soft tissue. A bone-tendon-bone graft comprises a length of soft tissue extending from a first assembled bone block to a second bone block and then doubles back to said first assembled bone block. Depending upon the embodiment, the second bone block fixedly or slideably attaches to the length of soft tissue and facilitates it doubling back to the first assembled bone block.

Open chambered spacers, implanting tools and methods are provided. The spacersinclude a bodyhaving a wallwhich defines a chamberand an openingin communication with the chamber. In one embodiment the wallincludes a pair of armsfacing one another and forming a mouthto the chamber. Preferably, one of the armsis truncated relative to the other, forming a channel. In one aspect the bodydoes a bone dowel comprise an off-center plug from the diathesis of a long bone. The toolsinclude spacer engaging means for engaging a spacer and occlusion means for blocking an opening defined in the spacer. In some embodiments, the occlusion meansincludes a plateextendable from the housing. In one specific embodiment the platedefines a groovewhich is disposed around a fastenerattached to the housingso that the plateis sliceable relative to the housing

Open intervertebral spacer

Orthopedic bone block assembly

The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.

Assembled bone-tendon-bone grafts

Bone block assemblies and their use in assembled bone-tendon-bone grafts

The present invention is directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both.

Intermediate bone block and its use in bone block assemblies and assembled bone-tendon-bone grafts

Growing community of inventors

Gainesville, FL, United States of America

John R Bianchi