Raindance Technologies, Inc.

Other

Bio-rad Laboratories, Inc.

John Q Lu

Jonathan Marc Rothberg

Wolfgang Hinz

Darren Roy Link

Michael Weiner

David Marran

Gilbert Feke

Ahmadali Tabatabai

Laurent Boitard

Jeffrey Branciforte

Yves Charles

Tate Maloy

Jonathan M Rothberg

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

Microfluidic devices and methods of use in the formation and control of nanoreactors

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

A training and/or exercise device and method for exercising muscle groups of the entire body is disclosed herein that is portable, easy to use, can work the muscles of the entire body, and does not have complicated integrating parts when in use. The device and method allows a free range of motion about a vertical axis without substantial resistance. The device allows a wide variety of movement using a single device, and particularly allows for balancing movements that are advantageous for strengthening the core. Further, the training device is particularly advantageous for use in a home gym and may be stored under a bed or within the overhead compartment of an airplane.

Training device for exercising muscle groups of the entire body

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Gullford, CT, United States of America

John Q Lu