Biomerieux, Inc.

Biomerieux Sa

Biomerieux D.p.i.

Ghirardi, Sandrine

John Perry

Sylvain Orenga

Arthur James

Stephen Stanforth

Vindhya Salwatura

Olivier Fabrega

Gilles Zambardi

Marie Cellier

Celine Roger-Dalbert

Céline Roger-Dalbert

Annette Rigby

Vanessa Chanteperdrix

Nathalie Bal

Daniel Monget

Rosaleen Joy Anderson

Sandrine Ghirardi

Marie-Pierre Bourguignon

Diane Halimi

Michel Peyret

Mark Gray

Keng Tiong Ng

Linda Varadi

Audrey Perry

Kerry Asir

Clair Preece

Laszlo Kondacs

Rosaleen Anderson

Alexandre F Bedernjak

Vindhya Lakshika Salwatura

Nathalie Bal Brossard

CÉLINE Roger-Dalbert

A new compound exhibiting particularly advantageous antibacterial properties, and having the structural formula: L-pyroglutamyl-L-1-aminoethyltetrazole (or N-(1-(1H-tetrazol-5-yl)ethyl)-5-oxopyrrolidine-2-carboxamide). Also, the use of this compound in microbiological culture methods and media intended for the detection, identification, enrichment, counting and/or isolation of target microorganisms that may be encountered in samples taken for clinical diagnosis or microbiological health control purposes.

Antibacterial compound and uses of same

A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.

Medium for the specific detection of resistant microorganisms

A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising:

Microorganism detection method comprising at least one alkyl(thio)glycoside

A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4'-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibitingbacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.

Enrichment and selective culture of mycobacteria

Micro-organism detection medium comprising at least one alkyl(thio)glycoside

An antimicrobial compound, as well as the salts, derivatives and analogs thereof, said compound being represented by the general formula (I): wherein Rrepresents a peptide part P1 or a peptide part P2.

Antimicrobial compounds

Disclosed is a process for detecting and/or identifying, in a biological sample, bacteria exhibiting a resistance to carbapenems, including: a) contacting said sample with a reaction medium including at least one chromogenic agent and faropenem and/or doripenem; b) incubating the whole so as to allow the bacteria to grow; and c) detecting the strains exhibiting a resistance to carbapenems. The medium employed in step a) also contains cloxacillin and/or a combination of cloxacillin and PAbetaN.

Detection of bacteria exhibiting a resistance to carbapenems

The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W, W, Wand Ware independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; X is NR, CZZ, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Zand Zbeing an alkyl; Y is N or NR, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; Z, Z, Zand Zare independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same. 

Nitroreductase enzymatic substrates

The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W, W, Wand Ware independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U is N or NR and V is CZN or NR or V is N or NR and U is CZ, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z, Z, Z, Z, Zand Zare independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.

The present invention relates to the use of a compound of the following formula (I), as an enzyme substrate for the detection of a peptidase activity or as a pH indicator: according to which:

Peptidase substrates

The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity or as an enzymatic substrate for the detection of a nitroreductase activity and indicator of pH, wherein: 

The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: 

The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which:

The present invention relates to a method for identifying at least two groups of microorganisms expressing the same enzymatic activity, comprising the following steps:

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Newcastle upon Tyne, United Kingdom

John Perry