Drexel University

Tbt Group, Inc.

John-Paul McGovern

Wan Y Shih

Wei-Heng Shih

Joseph Albert Capobianco

Qing Zhu

Zuyan Shen

Huidong Li

Hakki Yegingil

Christian Martorano

Sabine Ohler

Daniel DeClement

Matthew H Foster

Richard Martorano

A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data corresponding to the target substance, which advantageously results in fewer and/or smaller false-positive signals corresponding to non-target substances compared to those produced with the fluid being stationary. In various embodiments, the label-free interrogation method can be electro-mechanical and/or optical.

Flow-based enhancement of specificity for label-free biochemical assays

A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.

Piezoelectric microcantilever sensors for biosensing

A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer. The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.

In one aspect, the invention relates to a headset that includes an element that generates energy in response to forces. The headset includes at least one vibratable piezoelectric element; a first circuit element in electrical communication with the at least one vibratable piezoelectric element; and a signal processing element, the signal processing element disposed within the headset and at least partially energized by mechanical changes in the vibratable piezoelectric element.

Self-powering headset, devices and related methods

Growing community of inventors

Philadelphia, PA, United States of America

John-Paul McGovern