Nocimed, Inc.

Shifamed Holdings, LLC

Tivic Health Systems Inc.

Surx, Inc.

Nexalin Technology, Inc.

Apama Medical, Inc.

Aclarion, Inc.

University of California

Boston Scientific Scimed, Inc.

Nocira, LLC

Advanced Cardiovascular Systems, Inc.

Medasonics, Inc.

Verathon Inc.

Solarant Medical, Inc.

Microcurrents

John Patrick Claude

James Clayton Peacock, Iii

Paul Henry Kane

Amr Salahieh

Jonah Lepak

Tom Saul

Frank W Ingle

Brian D Brandt

Christopher A Wiklof

Garry L Carter

Paul L Do

Ricardo Dario Pradenas

Brian J Mosel

Robert J Laird

Emma Leung

Emma Lepak

Adnan I Merchant

Jeffrey Charles Lotz

David Mager George

Kevin E Willey

Claudio Argento

Thilaka S Sumanaweera

George A Morrison

Zak West

Mark H White

David C Densow

Andy Edward Denison

Darrin James Kent

Janine C Robinson

Loren L Roy

TOm Saul

Donald L Alden

Rodica Schileru

Gerald Lyons

Mary B Michaels

Daniel Lundberg

Blake Gurfein

Ron Avisa

Guy McNally

Thomas Breton

Paul A Hing

Stephen L Young

Jennifer Ernst

James Clayton Peacock Iii

Guy Mcnally

James Clayton Iii Peacock

James C Iii Peacock

Transcranial electro-stimulation device

An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

MR spectroscopy system and method

Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the cortex region of a patient's brain for treating opioid use disorder and substance use disorder. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Alternating current dynamic frequency stimulation system and method for opioid use disorder (OUD) and substance use disorder (SUD)

Caloric stimulation and pressure stimulation can be applied to the ear for treatment of neurological disorders, such as migraine, pain, and headache. Heat can be applied first to increase the sensitivity of the mechanoreceptors in the ear. The pressure can be applied after heating to produce a stronger neurological response than would occur without the heating. In some cases, cooling can be used. Valves can be used to direct fluid flow to a right ear, a left ear, or both. Valves can be used to transition the system between an irrigation or caloric mode and a pressure mode. Green eyewear can be used for therapeutic relief.

Systems and methods for treating neurological disorders

Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit. Sections of the ROF may be excluded from the polynomial fit, such as for example sections determined to be associated with relevant spectral peaks.

Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method

A microcurrent treatment device includes an adaptive trigger circuit configured to dynamically determine a triggering threshold for applying a therapeutic microcurrent via a treatment electrode to a nerve node on a person's face for treatment of a sinus condition.

Adaptive trigger for a microcurrent stimulation device

Transcranial electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the occipital region of a patient's brain. By stimulating the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation, especially those in which result in a resultant rectified direct current component being administered to the patient. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Transcranial alternating current dynamic frequency stimulation (TACS) method for Alzheimers and dementia

Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the frontal cortex region of a patient's brain. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation, especially those in which result in a resultant rectified direct current component being administered to the patient. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Transcranial alternating current dynamic frequency stimulation method for anxiety, depression, and insomnia (ADI)

Transcranial alternating current dynamic frequency stimulation (TACS) system

A magnetically driven pressure generator including a housing, flexible member, first magnetic force generator, and second magnetic force generator. The magnetically driven pressure generator oscillates the flexible member to increase or decrease the volume of a chamber, inversely increasing or decreasing the pressure of the chamber.

Magnetically driven pressure generator

MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs

Cardiac tissue ablation catheters including an inflatable and flexible toroidal or spherically shaped balloon disposed at a distal region of an elongate member, a flexible circuit carried by an outer surface of the balloon, the flexible circuit including, a plurality of flexible branches conforming to the radially outer surface of the balloon, each of the plurality of flexible branches including a substrate, a conductive trace carried by the substrate, and an ablation electrode carried by the substrate, the ablation electrode in electrical communication with the conductive trace, and an elongate shaft comprising a guidewire lumen extending in the elongate member and extending from a proximal region of the inflatable balloon to distal region of the inflatable balloon and being disposed within the inflatable balloon, wherein a distal region of the elongate shaft is secured directly or indirectly to the distal region of the inflatable balloon.

Ablation catheters

Systems for controlling ablation procedures that include a user interface. The user interface can include a display; and a memory with a computer executable method stored thereon, the computer executable method adapted to cause to be displayed on the display a plurality of interactive elements for controlling one or more aspects of the ablation.

Methods and systems for controlling energy delivery in medical devices

An ablation catheter including an elongate shaft, an inflatable balloon positioned at a distal region of the elongate shaft, a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon, a first ultrasound transducer disposed outside of the inflatable balloon, and a flexible circuit. The flexible circuit includes a first conductor and a second conductor and is disposed outside of and carried by the outer surface of the inflatable balloon. The first conductor is in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer.

Tissue ablation and monitoring thereof

Growing community of inventors

Redwood City, CA, United States of America

John Patrick Claude