Flagship Pioneering Innovations V, Inc.

Inari Agriculture Technology, Inc.

Flagship Pioneering Innovations Vi, LLC

Inari Agriculture, Inc.

John Patrick Casey, Jr

Yajie Niu

Randall William Shultz

Maria Margarita D Unson

David Arthur Berry

Michael Lee Nuccio

Michael Andreas Kock

Davide Sosso

Spencer Cory Peck

Richard Bailey Flavell

Steven John Taylor

Timothy F Briggs

Kathleen Nudel

Jennifer A Raji

Bernard Lanter

Mi-Jeong Kim

Eva Konecna

Koji Yasuda

Leonard Buckbinder

Cheri Snedeker

Jessica Alexander

Anna Liang

Dinara Gunasekera

John Robert Proudfoot

Barry Andrew Martin

Tomás Cermák

Ferdinand Edward Massari

Jenny Liu

Angela She

Diana Le

Amir H Moarefi

Afrand Kamali Sarvestani

Frank Anthony Skraly

Ignacio Martinez

Hok Hei Tam

Jonathan Dallas George Jones

Maria Helena Christine Van Rooijen

Nataliya Vladimirovna Nukolova

Brian Prescott Fiske

Kristine Yu

Devin Forest Reed Doud

Elijah Lane Bogart

Maier Steve Avendaño Amado

Piotr Stanislaw Kowalski

Tomáš Cermák

Robert Walter Myers

Cheri Ross

Joo Hyun Im

Dervla Tamara Isaac

Siddharth Dilipkumar Patel

Roman Lvovitch Bogorad

Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.

Modification of plant messenger packs with charged lipids

Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

Acylated active agents and methods of their use for the treatment of autoimmune disorders

Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Conjugates and methods of using the same

The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.

Methods for efficient tomato genome editing

The disclosure relates to precise modifications in wheat plant genomes including the heterologous integration of nucleic acid sequences that include a regulatory element at a predetermined locus. Also provided are wheat cells, wheat plants, wheat seeds, and processed wheat products comprising the modified wheat genomes.

Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants

Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a plant cell or plant protoplast. Further disclosed are methods using an RNA-guided nuclease to alter a target nucleotide sequence in a cell or protoplast of a plant; embodiments of such methods include treatments with chemical or physical reagents or treatment of the cell or protoplast with a specific thermal regime, such as a heat treatment.

Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA

Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease

The disclosure relates to improvements in methods for efficient editing of two or more endogenous soybean genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the soybean genome.

Methods for efficient soybean genome editing

The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.

Method of creating a plurality of targeted insertions in a plant cell

The invention relates to novel maize plants, seeds and compositions, as well as improvements to maize plant breeding and methods for creating modifications in maize plant genomes.

Methods for efficient maize genome editing

Rice cells and rice plants

Growing community of inventors

Boston, MA, United States of America

John Patrick Casey, Jr