American Home Products Corporation

Wyeth

John Wyeth Brother, Limited

John Wyeth & Bro., Limited

John P Yardley

Magid A Abou-Gharbia

Wayne E Childers, Jr

Horace Fletcher, Iii

John H Musser

Anthony F Kreft, Iii

John W Ullrich

John A Moyer

G E Husbands

Eric A Muth

Thomas W Pattison

Wayne Everett Childers

Ian A Cliffe

Peter B Russell

Jerry L Malis

Gary Paul Stack

Arie Zask

Reinhardt Bernhard Baudy

Sie-Yearl Chai

Kenneth L Kees

Richard Dale Coghlan

Alan Corbin

Diane Barbara Hauze

Michael Gerard Kelly

Cesario O Tio

Alan C White

This invention provides O-&#x3b1;-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimehtylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): wherein the variables Rand Rare defined herein, and where the configuration at the steriogenic center (*) may be R, S, or RS (the racemate).

Ethers of O-desmethyl venlafaxine

Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity

Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT1A activity

Ethers of O-Desmethyl venlafaxine

Bicyclic antagonists selective for the &agr;v&bgr;3 integrin

Ethers of o-desmethyl venlafaxine

This invention provides anxiolytic/antidepressant agents of the formula: ##STR1## in which R.sup.1 is alkyl;

4-indolylpiperazinyl derivatives

This invention provides anxiolytic/antidepressant agents of the formula:

There are disclosed the use of the compounds of the formula (I) ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl or 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R.sup.2 is unsubstituted or substituted phenyl, benzyl, or pyrimidinyl wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R.sup.3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; and m is the integer from 2 to 5 and the pharmaceutically acceptable salts thereof.

Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of

There are disclosed compounds of the formula (I) ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R.sup.2 is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R.sup.3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; m is the integer from 2 to 5; and the pharmaceutically acceptable salts thereof.

Aryl- and heteroaryl piperazinyl carboxamides having central nervous

There are disclosed compounds of the formula (I) ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R.sup.2 is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R.sup.3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; m is the integer from 2 to 5; and the pharmaceutically acceptable salts thereof. The compounds of this invention which demonstrate selectivity at the 5-HT.sub.1A and 5-HT.sub.2 versus D.sub.2 receptor binding sites are useful as potential anxiolytic-antidepressant agents. Compounds of this invention with equal high affinity for the 5-HT.sub.1A and D.sub.2 -receptor binding sites are useful as mixed antipsychotic-anxiolytic agents. Compounds of this invention which demonstrate central cholinergic activity are useful in the treatment of senile dementia of the Alzheimer type (SDAT) and Huntingdon's chorea.

Aryl-and heteroaryl piperazinyl carboxamides having central nervous

The compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl;

Benzimidazole phosphono-amino acids

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Gulph Mills, PA, United States of America

John P Yardley