Vanderbilt University

Other

E.i. Dupont De Nemours and Company

Harvard College

The United States Government As Represented by the Department of Veterans Affairs

Triad National Security, LLC

University of Alaska

Biomagnetic Technologies, Inc.

John P Wikswo

Ronald S Reiserer

Dmitry A Markov

Philip C Samson

David K Schaffer

David Edward Cliffel

Lisa J McCawley

Franz Baudenbacher

Frank Emmanuel Block

Mark Andrew Stremler

Michael Geuy

Frederick R Haselton

William Hudson Hofmeister

Ales Prokop

John A Mclean

Randall S Reiserer

Gregory B Gerken

Joseph R Scherrer

Clayton M Britt

William J Matloff

Jennifer Robin McKenzie

Charles P Lin

Kevin Truett Seale

Parker Andrew Gould

Eugene J Leboeuf

Jonathan Mark Gilligan

Frank E Block, Jr

Yu P Ma

Loi T Hoang

Erik M Werner

Phillip C Samson

Jennifer R Mckenzie

W Hunter Tidwell

Chang Y Chung

Sven Eklund

R Robert Balcarcel

Owen McGuinness

Donald Elliot Ingber

Daniel Levner

Christopher David Hinojosa

Geraldine A Hamilton

Kevin Kit Parker

Richard Caprioli

Jeffrey S Chamberlain

Josue A Goss

Pulak Nath

Douglas N Paulson

Alan Lauder

Eric P Skaar

Jen-Huang Huang

Sandra J Rosenthal

Jeremy L Norris

Eugene C Hirschkoff

Robert Lewis Fagaly

William C Black, Jr

James R Marsden

Robert Cunningham

Anthony Bahinski

Gour S Choudhury

Rashi Iyer

Jeffrey M Davidson

Eugene A LeBoeuf

Jennifer Harris

Dana Borden Lacy

Duane Crum

Christopher G Bublitz

Alex Prokop

Danielle Gutierrez

Nicholas T Peters

Nicole D Muszynski

Melissa Farrow

Kyle Hawkins

Erica L Curtis

Bradley J Roth

Douglas J Hall

Nestor G Sepulveda

W Patrick Henry

Ayeeshik Kole

Hunter Tidwell

William G Jenks

Daniel J Staton

William O Richards

Leonard A Bradshaw

Javad Golzarian

John P Barach

John McLean

Charles Wright

Chris Janetopoulos

Stephen R Koch

Veniamin Yu Sidorov

Owen McGuiness

Alissa Weaver

Stacy Sherrod

Todd Monroe

James Pino

Andreas Augustinus Werdich

Frank E Iii Block

A fluidic device includes a fluidic chip having a fluidic network comprising a plurality of fluidic channels in fluidic communication with a plurality of input ports, at least one output port, and at least one sensing port; and an actuator configured to engage with the fluidic network to control each fluidic channel to switch between an open state in which fluidic flow through said fluidic channel is permitted and a closed state in which no fluidic flow through said fluidic channel is permitted, so as to selectively collect fluid from multiple inputs via the plurality of input ports, and direct either all of the multiple inputs to the at least one output port, or all but a single selected input to the at least one output port and the single selected input to the at least one sensing port to which an analytical instrument is operably connected.

Microfluidic systems for multiple bioreactors and applications of same

A fluidic system includes a fluid distribution network, and a fluid collection and sampling network; a plurality of fluidic modules fluidically coupled between the fluid distribution network and the fluid collection and sampling network in parallel; a systemic circulation and mixing reservoir; and a first pump, and a second pump, wherein the first pump is fluidically coupled between the systemic circulation and mixing reservoir and the fluid distribution network for withdrawing media from the systemic circulation and mixing reservoir and delivering the media to the fluid distribution network; and wherein the second pump is fluidically coupled between the fluid collection and sampling network and a sample vial for withdrawing effluent of the plurality of fluidic modules from the fluid collection and sampling network and delivering the effluent to one or more sample vials.

A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.

Continuous automated perfusion culture analysis system (CAPCAS) and applications of same

A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein.

Massively parallel, multiple-organ perfusion control system

Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones.

Microfluidic systems, pumps, valves, fluidic chips thereof, and applications of same

A robot for transporting a biodevice from one place to another place, comprising a body for carrying the biodevice; a driving assembly for driving the body in omnidirectional motion; a sensing unit for sensing at least a position and orientation of the body; and a control unit coupled to the driving assembly and the sensing unit for generating one or more control signals based on at least the sensed position and orientation of the body to drive the driving assembly so as to move the body to a desired place and to arrive with the correct orientation.

Robots and robotic systems for fluid handling and transport of biodevices and applications of same

In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates.

Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same

A push-pull micropump includes one or more pairs of channels configured to transfer one or more fluids, each channel pair having an aspiration channel and an injection channel; and an actuator configured to engage the one or more pairs of channels, wherein the actuator comprises a plurality of rolling members and a driving member configured such that when the driving member rotates, the plurality of rolling members rolls along the one or more pairs of channels to cause individually the one or more fluids to transfer through each channel pair simultaneously at different flowrates or the same flowrate, depending upon actuated lengths of the aspiration and injection channels of each channel pair, wherein an actuated length of a channel is defined by a length of the channel along which the plurality of rolling members rolls during a full rotation of the driving member.

Multichannel pumps and applications of same

The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates.

A system for applying and measuring tensions of a plurality of bio-object constructs includes a base; and a flexible body disposed on the base, wherein the flexible body defines a plurality of construct holes for accommodating the plurality of bio-object constructs, such that when the flexible body is bent, the bending of the flexible body causes tensions to be applied to the plurality of bio-object constructs, thereby causing displacements of the plurality of bio-object constructs.

Devices and methods for tension measurements and applications of same

A peristaltic micropump includes one or more flexible channels configured to transfer one or more pumped fluids, and an actuator configured to engage the one or more flexible channels and rotate about a central axis. The actuator includes a plurality of rolling elements and a driving element configured such that the driving element operably rotates about the central axis and each rolling element operably rolls about a respective axis that is not parallel to the central axis. The plurality of rolling elements is disposed between the one or more flexible channels and the driving element. The driving element includes a cage configured to capture the plurality of rolling elements such that the plurality of rolling elements is located at different radii from a center of the cage.

Peristaltic micropump and related systems and methods

A device for measuring a tension of a bio-object construct as it is being stretched that includes a microscope, a holding member for accommodating the bio-object, and a probe. The microscope includes a condenser, an objective and a stage positioned therebetween. The stage is movable along a horizontal plane. The holding member is fixable on the stage. The probe has a first end attached to the condenser, and a second end placed in the holding member. The stage operably moves such that the bio-object construct moves toward the second end of the probe and contacts with the second end of the probe, thereby causing a displacement of the second end of the probe and a displacement of the bio-object construct, which are used to measure the tension of the bio-object construct.

Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.

Bio-assessment device and method of making the device

Growing community of inventors

Brentwood, TN, United States of America

John P Wikswo