Glaxo Group Limited

John P Turnbull

John Joseph Partridge

Brian L Bray

Maynard Emanuel Lichty

Richard Storer

Chi L Mo

Clive Alwin Meerholz

Bernard Charles Halter

David Joszef Tapolczay

Mark Brian Schilling

Chemical process for preparing an optically active aminodiol

A process for removing osmium from an aqueous solution of nucleosides comprising adding hydrogen sulfide, an aromatic pi base such as pyridine, and a mineral acid. The osmium is precipitated out of solution.

Method for removing osmium from nucleosides

Synthesis of the triol of formula (I) or its amine-protected derivative from a cyclopentene of the formula (II) or its amine-protected derivative: ##STR1## via steps including oxidation to the aldehyde, migration of the double bond, reduction of the aldehyde moiety back to the alcohol grouping and 1,2-cis-dihydroxylation of the double bond.

Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a

A process is described for the preparation of carbocyclic guanosine from aristeromycin in a multi-step procedure, the final step of which is the hydrolysis of a compound of the formula ##STR1## wherein R.sup.1 represents a C.sub.1-6 alkyl group or an arylC.sub.1-4 alkyl group and R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrogen atom or a hydroxyl protecting group. Carbocyclic guanosine is an intermediate in the synthesis of carbocyclic analogues of nucleosides having use in therapy, particularly as antiviral agents.

Process for the preparation of a carbocyclic nucleoside analogue

Growing community of inventors

Greenford, United Kingdom

John P Turnbull