Ibis Biosciences, Inc.

John P Penhune

Richard Holmes Griffey

David J Ecker

Steven A Hofstadler

Stanley T Crooke

Rangarajan Sampath

John McNeil

Roland Stoughton

Karl H Rudnick

Duane J Knize

Cecil L Basham, Jr

Clifford T Lewis

Brons M Larson

Jonathan R Bar-on

Dennis P Murray

Dino J Sofianos

David W Robbins

Rapid and definitive bioagent detection and identification can be carried out without nucleic acid sequencing. Analysis of a variety of bioagents and samples, such as air, fluid, and body samples, can be carried out to provide information useful for industrial, medical, and environmental purposes. Nucleic acid samples of unknown or suspected bioagents may be collected, optimal primer pairs may be selected, and the nucleic acid may be amplified. Expected mass spectra signal models may be generated and selected, the actual mass spectra of the amplicons may be obtained. The expected mass spectra most closely correlating with the actual mass spectra may be determined using a joint maximum likelihood analysis, and base counts for the actual mass spectra and the expected mass spectra may be obtained. The most likely candidate bioagents may then be determined.

Methods and apparatus for genetic evaluation

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La Jolla, CA, United States of America

John P Penhune