Leland Stanford Junior University

Vermillion Corporation

Fibralign Corporation

Other

Ajinomoto Co., Ltd.

Cooke Pharma

John P Cooke

Christopher Heeschen

Eduard Yakubov

James Jang

Victor J Dzau

Eric Thomas Fung

Gary H Gibbons

Phillip Tsao

Helen M Blau

John Ramunas

Eiichiro Kimura

Michael Weis

Frances Lauri Johnson

Anjali Pathak

Michael V Paukshto

George R Martin

Philip S Tsao

Fujun Zhang

Tai Tian Lim

Andrew J Maxwell

Alan C Yeung

Sverin Schwarzacher

Ngan Fong Huang

Andrew Wilson

Hongjie Dai

Tai-Tung Yip

Mitchell Wayne Mutz

Jonathan B Rothbard

Gerald G Fuller

Robert F Balint

Tatiana Zaitseva

Edwin Chang

Xiao-Ying Meng

Guosong Hong

Robert C Robbins

Yohannes T Ghebremariam

Ken Y Lin

Christopher Heescheen

Elichiro Kimura

Murray H Kown

Shiro Uemura

Garrison C Fathman

Thomas Martin Radke

Jerry Chung-yu Lee

Martin Ng

Jenny C Wu

Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Compounds, compositions, methods, and kits relating to telomere extension

The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.

Activation of innate immunity for enhanced nuclear reprogramming of somatic cells with mRNA

Disclosed are methods for imaging lumen-forming structures such as blood vessels using near-infrared fluorescence in the NIR-II region of 1000-1700 nm. The fluorescence is created by excitation of solubilized nano-structures that are delivered to the structures, such as carbon nanotubes, quantum dots or organic molecular fluorophores attached to hydrophilic polymers. These nanostructures fluoresce in the NIR-II region when illuminated through the skin and tissues. Fine anatomical vessel resolution down to &#x2212;30 &#x3bc;m and high temporal resolution up to 5-10 frames per second is obtained for small-vessel imaging with up to 1 cm penetration depth in mouse hind limb, which compares favorably to tomographic imaging modalities such as CT and MRI with much higher spatial and temporal resolution, and compares favorably to scanning microscopic imaging techniques with much deeper penetration.

High resolution imaging using near-infrared-II fluorescence

Embodiments of the present invention relate to a therapeutic device (graft) comprising a collagen membrane having an aligned uniaxial or biaxial structure such that mammalian cells plated on the membrane align mainly along the direction of the collagen fibrils. In a further aspect, a graft comprising a substantially tubular body, wherein the body has an exterior surface, an interior surface, and at least one lumen extending therethrough such that a fluid flow through the lumen can direct mammalian cell migration. In a further aspect, mammalian cells or growth and angiogenic factors can be optionally attached to the exterior and/or interior surface of the substantially tubular body. In various aspects, the graft can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided.

Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly

Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically, embodiments of the present invention relate to medical devices, materials or constructs, such as conductive biocompatible polymers having one or more networks of metal nanowires that enhance tissue repair and regeneration using electromagnetic fields.

Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields

The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.

Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof

The present invention provides &#x3b2;2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.

&#x3b2;-2 microglobulin as a biomarker for peripheral artery disease

Beta-2 microglobulin as a biomarker for peripheral artery disease

The present invention provides methods of modulating angiogenesis in an individual, as well as methods of identifying a candidate agent that modulates angiogenesis, where such methods involve modulating and identifying agents that modulate expression of gene products of a subset of genes concordantly-regulated by agonists of nicotinic acetylcholine receptor (nAChR), bFGF receptor, and VEGF receptor.

Methods of modulating angiogenesis and screening compounds for activity in modulating angiogenesis

The present invention relates to use of &#x3b2;-2-microglobulin (B2M or &#x3b2;2M) and C-reactive protein (CRP) levels as biomarkers of peripheral artery disease and/or atherosclerosis.

BETA2-microglobulin and C reactive protein (CRP) as biomarkers for peripheral artery disease

Growing community of inventors

Palo Alto, CA, United States of America

John P Cooke