Cardiomedics, Inc.

John P Burrell

Marvin P Loeb

Ginger Johnson

Lawrence J Perkins

Robert J Sullivan

Circulatory assistance is provided in a non-invasive procedure safely and effectively using a microprocessor of an external counter pulsation device programmed to control the actuation of any or all of a plurality of valves, each of which is mounted on and in fluid communication with one of a plurality of individual inflatable bladders disposed in pockets within cuffs encasing the calves, thighs, buttocks, abdomen and/or chest of a person and an optional valve in fluid communication with the person's airway, in any desired sequence or order, toward the heart or toward the feet, either during diastole or systole, at desired inception times during the cardiac cycle, for selected durations and at chosen pressures, for treating a variety of cardiac, non-cardiac and circulatory conditions.

Devices and methods for non-invasively improving blood circulation

A method for treating patients suffering from left ventricular dysfunction, exhibited by a left ventricular ejection fraction (LVEF) less than normal, is disclosed. The method involves applying, during diastole, for a time period of about one hour, about five days each week for at least about seven weeks, an incrementally increasing therapeutic pressure to the patients' lower extremities, from the calves through the thighs and the buttocks. The hourly treatments are carried out at incrementally increasing peak diastolic/systolic pressure ratios (D/S Ratios) in the range of about 0.4:1 up to about 0.6:1 and thereafter at a D/S Ratio in the range of 0.5:1 to 1:1 for each consecutive hourly treatment, with the proviso that the average D/S Ratio over the entire treatment regimen does not exceed about 0.9:1.

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Tustin, CA, United States of America

John P Burrell