Amylin Pharmaceuticals, Inc.

Alkermes Pharma Ireland Limited

Alkermes, Inc.

Alkernnes Pharma Ireland Limited

John Ong

Henry R Costantino

Steven G Wright

Michael E Rickey

Joyce M Hotz

Mark S Fineman

Rajesh Kumar

Thean Yeoh

Troy Christensen

Christine Smith

David M Lokensgard

Robert N Jennings

Gregg Stetsko

Troy Christenson

Thean Y Yeoh

David Lokensgard

Henry Constantino

David Lokensgord

This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Polymer-based sustained release device

Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar

Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides compositions for enhancing the transmucosal absorption of bioactive peptides and proteins, such as exendin-4, PYY, PYY, and GLP-1 and their analogs and derivatives, wherein the compositions comprise an absorption enhancing mixture of a cationic polyamino acid and a buffer that is compatible with the polyamino acid. Also provided are methods for enhancing the transmucosal absorption and bioavailability of bioactive peptides and proteins using such compositions.

Methods and compositions for enhanced transmucosal delivery of peptides and proteins

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San Diego, CA, United States of America

John Ong