Trustees of the Colorado School of Mines

John Oakey

David W M Marr

Tieying Gong

Alexander V Terray

A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.

Cell sorting device and method of manufacturing the same

Laminar flow-based separations of colloidal and cellular particles

The present invention provides microfluidic optical waveguides and waveguide switches providing capability for multiple outlet paths for the fluid waveguides and optical signals contained therein. A microfluidic structure comprises a core inlet channel, one or more cladding fluid inlet channels intersecting with the core inlet channel downstream of a core inlet, and at least two outlet channels coupled to the core inlet channel and downstream of the cladding fluid channel. An optical source providing an optical signal is aligned with the core inlet channel. A waveguiding fluid is supplied to the core inlet channel and a cladding fluid supplied to each of the cladding channels. The waveguiding fluid and cladding fluid form an optical waveguide operable to transmit the optical signal. The flow rate of the cladding fluid is selectable to switch the optical waveguide between at least the first and second outlet channels.

Switchable microfluidic optical waveguides

The present invention relates to the use colloidal particles to realize photonic and microfluidic devices. In particular embodiments, colloidal particles are used to realize microfluidic a two-way valve, three-way valve, check valve, three-dimensional valve, peristalsis pump, rotary pump, vane pump, and two-lobe gear pump. In certain embodiments, actuation of an active element in the microfluidic structure is accomplished by electrophoresis, the use of an optical trap or &ldquo;tweezer&rdquo;, or the application of an electric field or magnetic field. In other embodiments, the application of an electrical field to colloidal particles that are substantially constrained to two dimensional movement is used to realize wave guides, filters and switches for optical signals.

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Golden, CO, United States of America

John Oakey