Gilead Sciences, Inc.

Gilead Pharmasset LLC

Virobay, Inc.

Axys Pharmaceuticals, Inc.

Aventis Pharmaceuticals Inc.

Schering Aktiengesellschaft

Syntex (u.s.a.) Inc.

Aventis Pharma S.a.

Quest Diagnostics Investments, Inc.

John O Link

Jeromy J Cottell

Darryl Kato

James G Taylor

Elizabeth M Bacon

Scott D Schroeder

Zheng-Yu Yang

Sheila M Zipfel

Winston C Tse

Teresa Alejandra Trejo Martin

William John Watkins

Michael Graupe

Ashley Anne Katana

Hyung-Jung Pyun

Jennifer R Zhang

Randall W Vivian

Evan S Krygowski

Randall Halcomb

Thorsten A Kirschberg

Qi Liu

Eda Y Canales

Chinh Viet Tran

Aesop Cho

Scott E Lazerwith

Michael L Mitchell

Chien-Hung Chou

Choung U Kim

Lianhong Xu

Hongtao Liu

Hongyan Guo

Jay P Parrish

Nathan E Wright

Elbert Chin

Jianyu Sun

Kirk L Stevens

Steven S Bondy

Roland D Saito

Yunfeng Eric Hu

Jeff A Zablocki

Richard L Mackman

Gary Bruce Phillips

Manoj C Desai

Jiayao Li

Carina E Cannizzaro

Adam James Schrier

Gediminas J Brizgys

Chandrasekar Venkataramani

Dustin S Siegel

Barton W Phillips

Tetsuya Kobayashi

John W Patterson

Michael O'Neil Hanrahan Clarke

Kevin S Currie

Adrian S Ray

Cheng Yong Yang

Dimitrios Stefanidis

Scott A Mitchell

Peter A Blomgren

Jeffrey E Kropf

Jianjun Xu

Gregory Notte

Seung H Lee

Juan A Guerrero

Zhongdong Zhao

Jie Liu

Hong Yang

In Jong Kim

Frank Halley

Haolun Jin

Musong Kim

Neil H Squires

Gayatri Balan

Michael Sangi

Qiaoyin Wu

Nathan D Shapiro

Julie Farand

Soon Hyung Woo

Chienhung Chou

Christopher T Clark

Kapil Kumar Karki

Ruben Martinez

Kerim Babaoglu

Paul A Roethle

Zhimin Du

Ryan McFadden

Paul Hrvatin

Aaron C Schmitt

Jayaraman Chandrasekhar

Jennifer R Lo

David John Aldous

Oliver L Saunders

Samuel E Metobo

Michael R Mish

Jie Xu

James T Palmer

John J Nestor, Jr

Hang Chu

Evangelos Aktoudianakis

Gary A Peltz

The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

HIV inhibitor compounds

The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

Therapeutic compounds for HIV virus infection

Therapeutics compounds for HIV virus infection

The invention provides a compound of Formula I:

The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

Capsid inhibitors for the treatment of HIV

Provided herein are compounds of Formula (I):

Pentacyclic derivatives as Zika virus inhibitors

The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

Therapeutic compounds

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Cot modulators and methods of use thereof

The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.

HIV protease inhibitors

The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

Anti-HIV compounds

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San Francisco, CA, United States of America

John O Link