Vectura Gmbh

Edward Mendell Co., Inc.

Sosei R&d Ltd.

Phoqus Pharmaceuticals Limited

Pharmakodex Limited

Ranbaxy Laboratories, Inc.

The University of Bath

Hoechst (uk) Limited

Britannia Pharmaceuticals Limited

Penwest Pharmaceuticals Company

J. Rettenmaier & Soehne Gmbh & Co. Kg

Andi-ventis Limited

Other

Conopco, Inc.

Phoqus Limited

John Nicholas Staniforth

Anand R Baichwal

Edward A Hunter

Robin Mark Bannister

Stephen William Eason

Gaetano Brambilla

Quentin John Harmer

David Alexander Vodden Morton

Bob E Sherwood

Rossella Musa

Michael John Tobyn

Haggis Harris

Linda Ann Reeves

Rajbir Gill

Julian Clive Gilbert

Andrew John McGlashan Richards

Matthew Green

David Morton

Lorenzo Ferrarini

Matthew Michael James Green

David A V Morton

Steven Paul Rannard

Trevor Gordon Page

Alison Jayne Foster

David John Duncalf

Himadri Sen

James Long

Dong Wang

Derek Alan Woodcock

John E Hogan

Iain Grierson McDerment

Brian Andrew Hills

Andrew James Elphick

Clifford M Davidson

Martin Paul Grosvenor

Naresh Talwar

Steven R Brown

Christopher John Althorpe

Matthew Wright

David J Davies

John E Rees

Brian J Meakin

David Ganderton

Rosella Musa

Lorenzno Ferrarini

David Bradley Brook Simpson

Gary Stephen Howard

Nicolas John Bowman

Daniele Chauvin

Yorick Kamlag

Sharon Ann Mills

Iain Grierson Mcderment

Matthew Michael Green

The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Manufacture of pharmaceutical compositions

The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.

Method of making particles for use in a pharmaceutical composition

A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.

The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

Pharmaceutical compositions for inhalation

The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not more than 2 &#x3bc;m with active particles, wherein the additive material is suitable for promoting the dispersal of active particles upon aerolisation of a dry powder in a dry powder inhaler.

Particles for use in a pharmaceutical composition

The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not more than 2 &#x3bc;m with active particles, wherein the additive material is suitable for promoting the dispersal of active particles upon aerolization of a dry powder in a dry powder inhaler.

A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

Pharmaceutical formulations for dry powder inhalers

Method of making composite particles for use in pharmaceutical compositions and composite particles and compositions thereof

A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.

Preparation of pharmaceutical compositions

Pharmaceutical compositions of hydrophobic surface-modified active substance microparticles for inhalation

A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.

Carrier particles for use in dry powder inhalers

Growing community of inventors

Bath, United Kingdom

John Nicholas Staniforth