University of California

Alcoa Inc.

Arconic Corporation

The J. David Gladstone Institutes

Ithaca College

Arconic Technologies LLC

Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Buck Institute for Research on Aging

John Newman

Jen C Lin

Ralph R Sawtell

Rajeev G Kamat

Gary H Bray

Eric M Verdin

Bruce D Hammock

Scott Michael Ulrich

Christophe H Morisseau

Raymond J Kilmer

Diana K Denzer

Cagatay Yanar

Jonathan S Weissman

Thomas N Rouns

In-Hae Kim

Takaho Watanabe

Sina Ghaemmaghami

Nicholas Ingolia

Roberto J Rioja

Dhruba J Chakrabarti

Paul E Magnusen

Gregory B Venema

Shawn J Murtha

James Daniel Bryant

Shawn Patrick Sullivan

David Allen Tomes, Jr

David J McNeish

Darl G Boysel

Gino Norman Iasella

Timothy A Hosch

Julien Boselli

Mario Greco

Brett P Connor

Paul Daniel Jones

Gavin Federick Wyatt-Mair

Ali Unal

Sung Hee Hwang

Jiang Zheng

Lloyd A Molby

William D Bennon

Paul Whetstone

John F Butler, Jr

Dhurba J Chakrabarti

Greg Venema

Tim Hosch

Shirley Gee

Gabriela Zurek

James C Riggs

Yanar Cagatay

In various embodiments a compound comprising the enantiomerically enriched S-isomer S-BHB-S-1,3-butanediol is provided along with methods of use thereof.

S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using same

Aspects of the present disclosure include fatty acid &#x3b2;-hydroxyester compounds (e.g., fatty acid esters of &#x3b2;-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid &#x3b2;-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.

Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same

The aluminum alloy product of an embodiment of the present invention includes a pair of outer regions and an inner region positioned between the outer regions. A first concentration of eutectic forming alloying elements in the inner region is less than a second concentration of eutectic forming alloying elements in each of the outer regions. Further, the aluminum alloy product has a delta r value of 0 to 0.10. The delta r value is calculated as follows: Absolute Value [(r_L+r_LT&#x2212;2*r_45)/2] and the r_L is an r value in a longitudinal direction of the aluminum alloy product, the r_LT is an r value in a transverse direction of the aluminum alloy product, and the r_45 is an r value in a 45 degree direction of the aluminum alloy product.

Aluminum alloy products

The present invention, in some embodiments, is a method of forming an O temper or T temper product that includes obtaining a coil of a non-ferrous alloy strip as feedstock; uncoiling the coil of the feedstock; heating the feedstock to a temperature between a recrystallization temperature of the non-ferrous alloy and 10 degrees Fahrenheit below a solidus temperature of the non-ferrous alloy; and quenching the feedstock to form a heat-treated product having am O temper or T temper. The non-ferrous alloy strip used in the method excludes aluminum alloys having 0.4 weight percent silicon, less than 0.2 weight percent iron, 0.35 to 0.40 weight percent copper, 0.9 weight percent manganese, and 1 weight percent magnesium.

Methods of off-line heat treatment of non-ferrous alloy feedstock

Medium chain fatty acid esters of &#x3b2;-hydroxybutyrate and butanediol and compositions and methods for using same

New 6xxx aluminum alloy strips having an improved combination of properties are disclosed. The new 6xxx new aluminum alloy strips are rolled to a target thickness in-line via at least a first rolling stand and a second rolling stand. In one approach, the 6xxx new aluminum alloy strips may contain 0.8 to 1.25 wt. % Si, 0.2 to 0.6 wt. % Mg, 0.5 to 1.15 wt. % Cu, 0.01 to 0.2 wt. % manganese, 0.01 to 0.2 wt. % iron; up to 0.30 wt. % Ti; up to 0.25 wt. % Zn; up to 0.15 wt. % Cr; and up to 0.18 wt. % Zr.

Methods of continuously casting new 6xxx aluminum alloys, and products made from the same

New 6xxx aluminum alloys having an improved combination of properties are disclosed. Generally, the new 6xxx aluminum alloys contain 1.00-1.45 wt. % Si, 0.32-0.51 wt. % Mg, wherein a ratio of wt. % Si to wt. % Mg is in the range of from 2.0:1 (Si:Mg) to 4.5:1 (Si:Mg), 0.12-0.44 wt. % Cu, 0.08-0.19 wt. % Fe, 0.02-0.30 wt. % Mn, 0.01-0.06 wt. % Cr, 0.01-0.14 wt. % Ti, and &#x2264;0.25 wt. % Zn, the balance being aluminum and impurities, wherein the aluminum alloy includes &#x2264;0.05 wt. % of any one impurity, and wherein the aluminum alloy includes &#x2264;0.15 in total of all impurities.

6xxx aluminum alloys, and methods of making the same

New magnesium-zinc aluminum alloy bodies and methods of producing the same are disclosed. The new magnesium-zinc aluminum alloy bodies generally include 3.0-6.0 wt. % magnesium and 2.5-5.0 wt. % zinc, where at least one of the magnesium and the zinc is the predominate alloying element of the aluminum alloy bodies other than aluminum, and wherein (wt. % Mg)/(wt. % Zn) is from 0.6 to 2.40, and may be produced by preparing the aluminum alloy body for post-solutionizing cold work, cold working by at least 25%, and then thermally treating. The new magnesium-zinc aluminum alloy bodies may realize improved strength and other properties.

Heat treatable aluminum alloys having magnesium and zinc

New 2xxx aluminum alloy bodies and methods of producing the same are disclosed. The new 2xxx aluminum alloy bodies may be produced by preparing the aluminum alloy body for post-solutionizing cold work, cold working by at least 25%, and then thermally treating. The new 2xxx aluminum alloy bodies may realize improved strength and other properties.

2xxx aluminum alloys, and methods for producing the same

Heat treatable aluminum alloy strips and methods for making the same are disclosed. The heat treatable aluminum alloy strips are continuously cast and quenched, with optional rolling occurring before and/or after quenching. After quenching, the heat treatable aluminum alloy strip is neither annealed nor solution heat treated.

Aluminum alloys and methods for producing the same

Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.

Methods for detecting modification resistant nucleic acids

Heat treatable aluminum alloys having magnesium and zinc and methods for producing the same

Growing community of inventors

Export, PA, United States of America

John Newman