Cook Medical Technologies LLC

Salviac Limited

John Neilan

David Vale

Eamon Brady

James Butler

Steven Horan

Gerard Treacy

Gerard Rabitte

Michael Ryan

Shay Joseph Lavelle

Vincent McHugo

Michael S Clancy

Brendan Casey

Paul Gilson

Patrick Griffin

Ronald John Kelly

Charles Taylor

David Murray

Gerry McCaffrey

Alison Liddy

Triona Campbell

Ronan Keating

Ronald Kellly

Ger Houlihan

Don Frawley

Fionán Keady

Vincent Mchugo

Darach McGrath

James C Merk

Gerard Rabbitte

Brent A Mayle

Fionan Keady

Melissa Anenden

Dean R Puckett

Paul David Devereux

Tiffani Cannon

Martin Keegan

Christophe Silien

Conor Dillon

Syed A M Tofail

Morgan Tierney

Darin Voorhies

Margaret Long

Sharon White

Aladin Mani

Rabah Mouras

Mark Murray

Ger Tracey

Darach Mcgrath

Syed AM Tofail

Gerard Thomas Treacy

Criostoir O Bhealtun

A medical device such as a stent () or medical balloon () is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.

Coated medical device and method of coating such a device

A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.

Medical device with plasma modified oxide layer and method of forming such a device

There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.

Regulation/modification of stent contact surface for polymer free drug coating

A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.

Bioactive agent coated medical device and method of coating such a device

A stent delivery system and method are provided. The stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first position and a second position. A proximal constraining member is positioned on a proximal end of the stent. A distal constraining member is positioned on a distal end of the stent. A restraining member disposed throughout a length of the elongate shaft and releasably engaged with at least one of the proximal constraining member and the distal constraining member, the restraining member having a proximal end and a distal end. The stent is in the first position, the distal restraining member applies an axial mechanical force to the distal constraining member.

Tube and suture stent introducer system

A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37&#xb0; C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.

Endoscopic needle stylet with enhanced-flexibility lengths

There are disclosed implantable medical devices and apparatus for treating implantable medical devices during production, so as to cause the implantable medical devices to have abluminal surfaces and luminal surfaces with different functional characteristics and in particular surface energies. The luminal surfaces of the medical device are preferably coated with carbon, so as to have a low surface energy, which reduces the risk of thrombi forming when implanted into a patient's vessels. The abluminal surfaces are treated so as to have a high surface energy, such that a therapeutic, preferably bioactive, material, such as a drug, can adhere to the abluminal surfaces and preferably without any need for a containment layer such as polymer or other matrix material. Once the therapeutic material has been delivered into the tissue wall, the stent can remain within the patient's vessel without leaving any delivery artefacts, as occurs with some prior art drug eluting medical devices.

Implantable medical device with differentiated luminal and abluminal characteristics

A medical device such as a stent () or medical balloon () is at least partially coated with a carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.

A medical device such as a stent () or medical balloon () is functionalised prior to coating with a bioactive material (), specifically by acidification or basification of the contact surface or surfaces () of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.

A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.

Woven stent device and manufacturing method

The present invention generally relates to methods for determining the presence and distribution of a polarization active material present in a coating. In one embodiment, the coating is present on an implantable device, for example an implantable stent.

Optical technique for coating characterization

A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Anti-aspiration prosthesis

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Gort, Ireland

John Neilan